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Printing spatially and temporally defined boundaries to direct the self-organization of cells and cellular aggregates to engineer functional tissues

Project description

Using bioprinted tissue to prevent osteoarthritis

Musculoskeletal disorders like osteoarthritis – a degenerative condition affecting millions of people worldwide – are the most common causes of chronic pain, disability and morbidity. Current treatments are limited in their efficacy. While musculoskeletal regeneration has become a prominent research area, regenerative strategies have failed so far to produce tissues mimicking the exquisite structural complexity of native tissues, dramatically limiting their clinical utility. In this context, the EU-funded 4D-BOUNDARIES project will use 3D bioprinting technologies to engineer, for the first time, patient-specific cartilage and meniscal grafts that mimic the internal and external anatomy and anisotropic mechanical properties of the native tissues. In the case of osteoarthritis, the ability to bioprint such functional tissues could prevent its development.

Host institution

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Net EU contribution
€ 2 390 615,00
Address
College Green Trinity College
D02 CX56 Dublin 2
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 390 615,00

Beneficiaries (2)

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Net EU contribution
€ 2 390 615,00
Address
College Green Trinity College
D02 CX56 Dublin 2

See on map

Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 390 615,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 312 500,00
Address
Belfield
4 Dublin

See on map

Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 312 500,00