Plasma epigenomics as an extension of liquid biopsy technologies
Genomic DNA carries a multitude of post-translational modifications that reflect cells’ transcriptional states. Upon cell death, fragmented chromatin retaining histone modifications is released into circulation. The EU-funded cfChIP project aims to obtain plasma epigenomic information and translate it into medically relevant findings via liquid biopsy and chromatin immunoprecipitation of cell-free nucleosomes with chromatin marks followed by sequencing (cfChIP-seq). The previous study showed that cfChIP-seq provides multidimensional epigenetic information about the identity and the transcriptional state of the originating cells. The project will explore plasma samples from patients and donors in combination with probabilistic modelling to find correlations between tissue gene expressions and circulating chromatin profiles and how the immune system changes with disease progression and response to treatments.
Fields of science
Funding SchemeERC-ADG - Advanced Grant
See on map