Project description
Signalling cascade of inflammasomes
Inflammasomes are cytosolic multiprotein oligomers that activate the inflammatory cascade and play a pivotal role in host defence. They function as intracellular surveillance systems, recognising the pathogens or indirectly responding to the perturbation of cellular homeostasis. The EU-funded ENGINES project aims to obtain a detailed framework for Nod-like receptor with pyrin domain 1 (NLRP1) and caspase activation and recruitment domain 8 (CARD8) inflammasomes’ functions. The project will employ omics technologies, cell biological, biochemical and structural biology approaches to elucidate the signalling upstream of NLRP1 and CARD8, the mechanism of action and the structure of these sensors. Screening of pathogen panels in combination with novel humanised mouse models will evaluate the relevance of these inflammasomes for antiviral immunity and immune cell homeostasis.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesbiological sciencescell biologycell signaling
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicinephysiologyhomeostasis
- natural sciencesbiological sciencesmolecular biologystructural biology
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
80539 Muenchen
Germany
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Beneficiaries (1)
80539 Muenchen
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