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environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Objective

ALTERNATIVE will develop an innovative platform able to detect the cardiotoxicity of chemicals and their bio-transformation products. The novel platform will enable regulators and industry to identify, quantify and prevent cardiotoxic co-exposures to industrial chemicals and pharmaceuticals in a cost-effective way. ALTERNATIVE will particularly focus on cardiotoxic effects on older people, which is of high relevance in view of the ageing EU population and the high spread of cardiovascular diseases.
The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool. In addition, ALTERNATIVE will modify the tissue model to reproduce the aged myocardial tissue and elucidate the adverse effects of chemicals on older people. ALTERNATIVE?s proof-of-concept validation will be performed on well-known mixtures of pollutants, affecting different environmental compartments, and selected via epidemiological, toxicological and modelling expertise.
ALTERNATIVE will also provide systematic reviews of high-quality epidemiological studies to support integrated in vitro and in silico data, giving a more robust basis for regulatory decisions.
The ALTERNATIVE platform will be an innovative tool for complying with the current regulation associated with the assessment of chemical compounds. It will be a new instrument to evaluate unpredictable toxicity due to synergistic effects of different chemicals, additionally worsened by the human ageing process.
By introducing an in vitro cardiac system and ML models, ALTERNATIVE will provide a platform able to refine, reduce and replace the need for animal testing, providing close-to-real scenario information on toxicity and achieving a significant reduction of the associated direct and indirect costs.

Call for proposal

H2020-LC-GD-2020-3
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Coordinator

POLITECNICO DI TORINO
Address
Corso Duca Degli Abruzzi 24
10129 Torino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 592 300

Participants (10)

SCIENSANO
Belgium
EU contribution
€ 460 051
Address
Juliette Wytsmanstraat 14
1050 Elsene
Activity type
Research Organisations
SI ES TI EOOD
Bulgaria
EU contribution
€ 198 750
Address
Al. Stamobliysky 18
6500 Svilengrad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELVESYS
France
EU contribution
€ 473 218,75
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 569 500
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
FUNDACIO EURECAT
Spain
EU contribution
€ 1 439 437,50
Address
Avenida Universitat Autonoma 23
08290 Cerdanyola Del Valles (Barcelona)
Activity type
Research Organisations
EURESCOM-EUROPEAN INSTITUTE FOR RESEARCH AND STRATEGIC STUDIES IN TELECOMMUNICATIONS GMBH
Germany
EU contribution
€ 468 250
Address
Wieblinger Weg 19/4
69123 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 386 750
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
IVTECH SRL
Italy
EU contribution
€ 306 750
Address
Via Di Bagnaia
55054 Massarosa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 362 500
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 242 250
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments