Project description
The role of mechanical forces in protein activity
Many biological processes including cell division, cell migration and development involve the sensing and transduction of mechanical forces. Proteins are an integral part of these processes, undergoing conformational changes in response to such forces. The EU-funded ProForce project aims to develop a method for measuring the impact of mechanical forces on single proteins. Researchers will focus on proteins known to be activated by force stimuli, such as the haemostatic von Willebrand factor, the focal adhesion kinase, which is implicated in cell migration and metastasis, and G-protein coupled receptors. Results will offer important insight into the ability of mechanical forces to regulate protein activity and may disclose novel targets for therapeutic intervention.
Fields of science
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
3584 CS Utrecht
Netherlands
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Beneficiaries (1)
3584 CS Utrecht
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