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EU-Africa Concerted Action on SAR-CoV-2 Virus Variant and Immunological Surveillance

Objective

Despite of the successful advances achieved to date in the fight against the COVID-19 pandemic with the development of vaccines and therapy, the worldwide propagation of SARS-CoV-2 has resulted in the rapid evolution of this virus and in the emergence of variants of concern (VOC) that may dampen the efficacy of the first generation vaccines. To tackle the challenges associated with the VOC, the CoVICIS program is proposing a global approach with a powerful state-of-the-art virologic and immunologic platforms coupled with large genomic surveillance studies and diverse cohorts in EU and SSA. This allows CoVICIS to contribute to the early identification of emerging VOC and address key unanswered questions regarding i) the susceptibility to infection with VOC after a prior infection in the setting of a long-COVID or after vaccination with different vaccines, ii) the risk posed by VOC in immunocompromised patients, and iii) the modalities of infection and immune responses in children. The diversity of the cohorts provides a unique opportunity to study virus evolution in different settings, where SARS-CoV-2-specific humoral and cellular immune responses are predicted to vary very significantly. Beyond the genomic surveillance, the ground-breaking research and innovation of the program is the characterization of virologic and immunologic properties of VOC and the identification of immune correlates of protection after disease or vaccination. CoVICIS’ ambitious goals are only achievable thanks to the existing population studies and cohorts funded by national and international public agencies and public-private partnerships, and the combined collective expertise of CoVICIS partners in the fields of epidemiology, genomics, virology, immunology, data science and public health.

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Net EU contribution
€ 1 885 117,00
Address
Rue Du Bugnon 21
1011 Lausanne
Switzerland

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,13

Participants (15)

SOUTH AFRICAN MEDICAL RESEARCH COUNCIL
South Africa
Net EU contribution
€ 650 000,00
Other funding
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 1 003 406,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,25
WITS HEALTH CONSORTIUM (PTY) LTD
South Africa
Net EU contribution
€ 250 000,00
Address
Princess Of Wales Terrace, Parktown, 31
2193 Johannesburg

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITY OF CAPE TOWN
South Africa
Net EU contribution
€ 650 000,00
Address
Private Bag X3
7701 Rondebosch

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 0,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

KLINIKUM DER UNIVERSITAT MUNCHEN
Germany
Net EU contribution
€ 560 875,00
Address
Marchioninistrasse 15
81377 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 700 000,00
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STIFTUNG SWISS SCHOOL OF PUBLIC HEALTH PLUS (SSPH)

Participation ended

Switzerland
Net EU contribution
€ 0,00
Address
Hirschengraben 82
8001 Zurich
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Other
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 1 511 016,00
Address
Via Festa Del Perdono 7
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,25
EUROVACC FOUNDATION
Switzerland
Net EU contribution
€ 293 750,00
Address
Place Saint-francois 1 Etude Kellerhals Carrard
1003 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Other
Other funding
€ 0,00
STICHTING INTERNATIONAL AIDS VACCINE INITIATIVE THE NETHERLANDS
Netherlands
Net EU contribution
€ 158 782,00
Address
Van Diemenstraat 20, 200 Unit 48
1013 NH Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 0,00
JIMMA UNIVERSITY
Ethiopia
Net EU contribution
€ 438 625,00
Address
Jimma University
Jimma

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STELLENBOSCH UNIVERSITY
South Africa
Net EU contribution
€ 450 000,00
Address
Victoria Street Administration B Building
7600 Stellenbosch

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,05
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 500 000,00
Address
Rue Du General Dufour 24
1211 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 997 400,00
Address
Ramistrasse 71
8006 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00