An agent-based simulation will help explain the behaviour of biomolecular condensates
Organisms are largely water with many interspersed biomolecules, compounds and ions. Within cells, these constituents form different compartments to fulfill functions. While large compartments are often surrounded by a membrane, most smaller compartments form spontaneously from the interactions among dispersed molecules. Consequently, these biomolecular condensates behave similarly to liquid droplets. Their malfunction is involved in diseases, including Alzheimer’s, Parkinson’s and cancer. The EU-funded EmulSim project will investigate how healthy cells control their condensates on all length scales to elucidate how they become malfunctioning in diseased states. The insight will lead to a novel agent-based simulation framework to support the development of new therapeutics.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Call for proposalSee other projects for this call
Funding SchemeHORIZON-AG - HORIZON Action Grant Budget-Based
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