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Developing novel inhaled bioengineered Extracellular Vesicle RNA based advanced therapeutics, delivered by tailored aerosol delivery technology for the treatment of lung cancer

Project description

Advancing aerosol therapeutics delivery to the lung

Extracellular vesicles (EVs) are membrane-enclosed structures actively secreted by cells as a means of intercellular communication in various biological processes. EVs have attracted great interest thanks to the therapeutic potential of their nucleic acid and protein cargo. The EU-funded INSPIRE project is exploiting EVs as delivery vehicles for transfer to the lung. To date, pulmonary gene therapy has been hampered by the inability of various nucleic acid vectors to penetrate the lung mucus and effectively reach lung cells. INSPIRE will employ an aerosol-based approach to efficiently deliver genetically modified EVs from mesenchymal stromal cells through the mucus barrier, as a therapy against lung cancer.

Coordinator

MYRIAD CONSULTING LIMITED
Net EU contribution
€ 129 827,50
Address
Guinness Enterprise Centre Taylor's Lane, Dublin 8
D08 C2F1 Dublin
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (7)

AEROGEN LTD
Ireland
Net EU contribution
€ 2 327 815,00
Address
Ida Business Park Dangan
H91 Galway

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Net EU contribution
€ 900 408,00
Address
College Green Trinity College
D02 CX56 Dublin 2

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,75
EVERZOM
France
Net EU contribution
€ 2 914 797,00
Address
24 Rue Du Faubourg Saint Jacques
75014 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,50
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
Net EU contribution
€ 197 500,00
Address
Im Neuenheimer Feld 280
69120 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 0,00
REMEDY BIOLOGICS LIMITED
Ireland
Net EU contribution
€ 562 500,00
Address
76 Racehill Park Racehill Manor
A84R970 Ashbourne Co Meath

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
PHARMALEX GMBH
Germany
Net EU contribution
€ 943 750,00
Address
Bahnstrasse 42-46
61381 Friedrichsdorf

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Region
Darmstadt Hochtaunuskreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
OMNISPIRANT LIMITED
Ireland
Net EU contribution
€ 4 801 997,50
Address
Rathronan
E91D9N2 Clonmel Tipperary

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Southern Mid-West
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00