Project description
Advancing aerosol therapeutics delivery to the lung
Extracellular vesicles (EVs) are membrane-enclosed structures actively secreted by cells as a means of intercellular communication in various biological processes. EVs have attracted great interest thanks to the therapeutic potential of their nucleic acid and protein cargo. The EU-funded INSPIRE project is exploiting EVs as delivery vehicles for transfer to the lung. To date, pulmonary gene therapy has been hampered by the inability of various nucleic acid vectors to penetrate the lung mucus and effectively reach lung cells. INSPIRE will employ an aerosol-based approach to efficiently deliver genetically modified EVs from mesenchymal stromal cells through the mucus barrier, as a therapy against lung cancer.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
D08 C2F1 Dublin
Ireland
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Participants (7)
H91 Galway
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
D02 CX56 Dublin 2
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75014 Paris
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
69120 Heidelberg
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A84R970 Ashbourne Co Meath
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
61381 Friedrichsdorf
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E91D9N2 Clonmel Tipperary
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.