Project description DEENESFRITPL Innovative injectable treatment for osteoarthritis Osteoarthritis (OA) affects millions of people around the globe and is the main cause of disability due to an aging population and the obesity epidemic. Knee joint OA brings severe pain and reduced mobility caused by progressive degradation of bone and cartilage. Scientific data shows that OA treatment requires multi-modal therapeutics. Relevium Medical in Ireland developed Hydrobloc that regenerates the damaged cartilage. provides pain relief and improves joint function through a cushioning lubricant effect. Preclinical studies demonstrated the return to 90% of normal joint function level. The EU-funded ARTIGEL project will conduct validation of the pre-clinical results in large animal models and the development of a business plan for transition to commercialisation. Show the project objective Hide the project objective Objective Osteoarthritis (OA) is an incurable complex disease affecting an estimated 240 million people globally including 40 million Europeans . OA is the fastest growing cause of disability due to an aging population and the obesity epidemic and affects more people each year than cancer and heart disease. In knee OA progressive degradation of bone and cartilage in the joint results in severe pain and reduced mobility. Current treatments for Knee OA target only one aspect of the disease, yet most recent scientific data highlight the need for multi-modal therapeutics to treat this complex disease. Furthermore, the limitations of treatments force 80% of patients to rely on strong, addictive pain medication. Through the Hydrolieve ERC proof of concept grant, it was proven that Hydrobloc, statistically significantly reduced pain sensations in an in vivo pain model. These exciting results led Dr Alison Liddy to spin-out Relevium Ltd.Hydrobloc unique synergistic triple action addresses all aspects of this debilitating disease. Hydrobloc is the only therapeutic that regenerates the damaged cartilage whilst providing immediate, superior pain relief, and improving the physical function of the joint through a cushioning lubricant effect. Pre-clinical studies have proven that Hydrobloc returns the OA joint to 90% of normal (non-OA) physical function.With this EIC grant, Relevium is partnering with NUI Galway to validate the pre-clinical results in larger animals and preclinically test for other OA indications. Relevium will compile the clinical trial dossier and develop a business model towards the maturation and transition to commercialisation. Fields of science engineering and technologymechanical engineeringtribologylubricationmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugssocial scienceseconomics and businessbusiness and managementbusiness modelsmedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencesnutritionobesity Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2021-TRANSITIONOPEN-01 - EIC Transition Open 2021 Call for proposal HORIZON-EIC-2021-TRANSITIONOPEN-01 See other projects for this call Funding Scheme HORIZON-AG - HORIZON Action Grant Budget-Based Coordinator RELEVIUM MEDICAL LIMITED Net EU contribution € 1 452 500,00 Address 7 tor bui cappagh road H91 PRC6 Galway Ireland See on map Region Ireland Northern and Western West Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. NATIONAL UNIVERSITY OF IRELAND GALWAY Ireland Net EU contribution € 945 615,00 Address University road H91 Galway See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
