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V A L I D A T E - Validation of a Trustworthy AI-based Clinical Decision Support System for Improving Patient Outcome in Acute Stroke Treatment

Objective

Based on previously developed models and an existing prototype of a clinical decision support system (patent pending), we set out in this project to further develop, test, and validate this clinical decision support for the treatment stratification of acute stroke patients to improve patient outcome. Machine learning (ML)-enabled Artificial intelligence (AI) methods are increasingly adopted in the medical field. Implementing ML-based CDSSs have the potential to be go beyond the current clinical state-of-the-art as AI excels at finding complex and non-linear relationships across a multitude of prognostic variables. AI also has the promise to combine different modalities, such as imaging and clinical values, leading to powerful stratification tools accounting for a multitude of patient sub-populations. Our consortium combines excellence in technical and medical machine learning development with the clinical expertise of three leading stroke hospital partners. Additionally, our consortium benefits from the special expertise in the development of trustworthy AI, software design, and the translation of AI models to the clinical setting with focus on the regulatory process. By leveraging the available medical data and exploiting technological opportunities in the field of AI, and developing and validating trustworthy AI solutions to be implemented in the clinical workflow we are seeking to surpass the clinical state-of-the-art by making a significant and sustainable impact on the treatment of acute stroke that will improve patient survival, outcome and quality of life. The results of our work will serve as a pathway for future projects and we will make our experiences public in the form of standard operating procedures (SOPs) in the areas of development, testing, validation, and regulatory processes.

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 1 220 625,00
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (9)

EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH
Germany
Net EU contribution
€ 617 500,00
Address
Oxfordstrasse 2
53111 Bonn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
TECHNOLOGICAL UNIVERSITY DUBLIN
Ireland
Net EU contribution
€ 472 125,00
Address
North Circular Road 191 Park House Grangegorman
D07 EWV4 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SIMULA METROPOLITAN CENTER FOR DIGITAL ENGINEERING AS
Norway
Net EU contribution
€ 351 875,00
Address
Pilestredet 46 Oslo Metropolitan
0167 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
Net EU contribution
€ 756 350,00
Address
Im Neuenheimer Feld 672
69120 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HADASSAH MEDICAL ORGANIZATION
Israel
Net EU contribution
€ 700 000,00
Non-EU contribution
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 567 950,00
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IBM IX BERLIN GMBH
Germany
Net EU contribution
€ 840 000,00
Address
Chausseestrasse 5
10115 Berlin

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Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STROKE ALLIANCE FOR EUROPE
Belgium
Net EU contribution
€ 154 250,00
Address
Rue Washington 40
1050 Brussels

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00
NORAHEALTH SL
Spain
Net EU contribution
€ 237 500,00
Address
Rambla Jardi 110
08197 Sant Cugat Del Valles

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00