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Improving bioproduction through dynamic regulation circuits

Project description

Designs for more robust microbial strains

Microbial robustness is important for sustainable and efficient biotechnology-based production. Producer strains created in the laboratory do not always respond well to industrial conditions like large fermentation volumes, accumulation of toxic intermediates and media acidification. The Marie Skłodowska-Curie Actions (MSCA) project BioCircus will address the issue caused by the lack of robustness in engineered microbial strains. Specifically, it will explore the construction of biosensor and dynamic regulation circuits that measure and control the production of the target molecule. It will also use machine learning predictive models and automation to improve these circuits. Naringenin, a key molecule of the flavonoid family, will be used as proof-of-principle molecule. E. coli will be used as model organism.

Coordinator

UNIVERSITAT POLITECNICA DE VALENCIA
Net EU contribution
€ 206 641,20
Address
Camino De Vera Sn Edificio 3a
46022 Valencia
Spain

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Partners (1)

BIOPOLIS SL
Spain
Net EU contribution
No data
Address
Calle Catedratico Agustin Escardino Benlloch 9 Parque Cientifico De La Universidad De Valencia
46980 Paterna Valencia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data