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Discovering Collagen I degradation process in chronic diseases with fibrotic component

Objective

Fibrosis-related chronic diseases (CDs) are amongst the biggest societal burdens in Europe, with fibrosis being recognised as the main driver of morbidity and mortality. Extracellular matrix (ECM) is a key player in fibrosis, with an excessive accumulation of type I collagen (COL1) being a predominant component of the fibrotic tissue. While the increase in COL1 production is considered a main driver of fibrosis, respective drugs had limited efficacy. New evidence indicates that attenuation of COL1 degradation is highly relevant, contributing to onset and progression of fibrosis. Ambitious early stage researchers (ESRs) will join forces within a multi-disciplinary, comprehensive and inter-sectoral doctorate training programme, embedded in an existing network of excellent research groups across Europe, to investigate the “outside-the-box idea” on impaired COL1 degradation being a key driver of fibrosis. The main scientific goal is to improve the understanding of molecular mechanisms associated with COL1 degradation in major fibrosis-related CDs, and investigate the disruptive hypothesis of attenuated COL1 degradation being the key driver of fibrosis and a major contributor to onset and progression of CDs. This will be achieved through multi-disciplinary research and training combining state-of-the-art –omics approaches and data (peptidomics, proteomics and transcriptomics) in a bioinformatics framework, followed by in- and ex-vivo investigation, complemented with ESRs training on translational skills and competences. Such a programme will train a new generation of translational researchers able to covert ideas into products, and will have a profound impact on their employability, and competitiveness. The project will progress beyond the state of the art and provide the currently missing fundamental knowledge on the molecular pathophysiology of COL1 degradation, setting up the stage for novel biomarkers and anti-fibrotic therapies.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 164 904,60
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
No data

Participants (4)

NORDIC BIOSCIENCE A/S
Denmark
Net EU contribution
€ 402 384,00
Address
Herlev Hovedgade 205-207
2730 Herlev

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
RD NEPHROLOGIE SAS
France
Net EU contribution
€ 400 482,60
Address
2 Rue Des Muriers
34000 Montpellier

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
Net EU contribution
€ 160 065,60
Address
Soranou Efesiou 4
115 27 Athina

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Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Research Organisations
Other funding
No data
MOSAIQUES DIAGNOSTICS GMBH
Germany
Net EU contribution
€ 521 078,40
Address
Rotenburger Strasse 20
30659 Hannover

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Hannover Region Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data

Partners (4)

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
Net EU contribution
€ 0,00
Address
6 Christou Lada Str
10561 Athina

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Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Higher or Secondary Education Establishments
Other funding
No data
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 0,00
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITAETSKLINIKUM AACHEN
Germany
Net EU contribution
€ 0,00
Address
Pauwelsstrasse 30
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITE PAUL SABATIER TOULOUSE III
France
Net EU contribution
€ 0,00
Address
Route De Narbonne 118
31062 Toulouse Cedex 9

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Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Higher or Secondary Education Establishments
Other funding
No data