Targeting toxin-related amyloids of Staphylococcus aureus
Usually found on human skin and in the nose, the bacteria Staphylococcus aureus can eventually become pathogenic, causing community and healthcare-acquired infections. Using atomic force microscopy alongside complementary multiscale biophysical tools, the EU-funded PSMNano project aims to study the role of toxins, called phenol-soluble modulins (PSM), secreted by S. aureus and highly associated to their virulence. Researchers are notably interested in investigating how PSMs interact with host membranes and cause either cytotoxicity or inflammation, depending on the structure they adopt (monomeric vs. fibrils). Understanding the fundamental roles of PSM in S. aureus pathogenesis is fundamental to the identification of therapeutic targets and the design of novel treatments, eliciting less resistance than traditional antibiotics.
Fields of science
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Call for proposalSee other projects for this call
Funding SchemeMSCA-PF - MSCA-PF
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