An in vitro model of the perivascular niche
The microenvironment around blood capillaries is known as the perivascular niche and plays an important role in various conditions, including neuroinflammation. The scope of the B3M project funded by the European Research Council is to study the perivascular niche of cerebral vessels by recreating it in vitro. Using hydrogels with tunable properties as a scaffold and endothelial cells derived from induced pluripotent stem cells, researchers will recapitulate the architecture and function of the in vivo perivascular niche. The in vitro system will allow investigation of the cellular and molecular events that dictate leukocyte penetration of the perivascular niche leading to neuroinflammation.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme