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STOP SPREAD BAD BUGS: novel antimicrobial approaches to combat multidrug resistance in bacteria

Objective

STOP SPREAD BAD BUGS is a new multi-disciplinary research/training consortium built to combat the alarming problem of global antimicrobial resistance. Multi-drug resistance (MDR) in bacteria is becoming increasingly common thus urgently calling for alternative approaches to develop and implement novel antibiotics. We envision a definitive solution that will require a paradigm shift. Its foundation shall be the training of a new generation of future 15 Early Stage Researchers (ESRs) by world-renowned experts in the field of drug development, infectiology, immunology and pharmacology. A unique state-of the-art teaching/training pipeline shall be developed across 7 academic and 5 SME partners with complementary expertise in the development and testing of novel approaches to antimicrobial therapy in humans. We shall establish knowledge and expertise on carbohydrate and protein chemistry for the discovery of new drug candidates, while characterizing the underlying mechanism of existing compounds for treatment of microbial infections. Computational modelling shall optimize the interactions of the novel entities with selected pathogens. A range of infection models allows partners to simultaneously determine compound efficacy in pre-clinical settings and investigate the potential effects of the novel antimicrobials on host tissues. State-of-the-art imaging tools will be applied to track the bacteria and novel compounds in these test systems. Uniquely, the pipeline will also determine the pharmacokinetics, and the effects of compounds on host microbiota and host immunity. Understanding the mechanisms of action of the novel antimicrobials shall provide insights into new antimicrobial mechanisms, which may be further exploited in spin-off projects. This approach means that the STOP SPREAD BAD BUGS consortium will deliver uniquely trained, multi- and interdisciplinary ESRs that will take the continuing fight against global MDR safely into the future.

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Net EU contribution
€ 548 740,80
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (12)

TISSUEGNOSTICS GMBH
Austria
Net EU contribution
€ 405 496,80
Address
Taborstrasse 10/2
1020 Vienna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Net EU contribution
€ 286 488,00
Address
College Green Trinity College
D02 CX56 Dublin 2

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 411 555,60
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
No data
PHILIPPS UNIVERSITAET MARBURG
Germany
Net EU contribution
€ 130 269,60
Address
Biegenstrasse 10
35037 Marburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITETET I STAVANGER
Norway
Net EU contribution
€ 297 748,80
Address
Kjell Arholms Gate 41
4021 Stavanger

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Region
Norge Vestlandet Rogaland
Activity type
Higher or Secondary Education Establishments
Other funding
No data
HYLOMORPH AG
Switzerland
Net EU contribution
€ 446 439,60
Address
Technoparkstrasse 1
8005 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
INBIOSE
Belgium
Net EU contribution
€ 262 620,00
Address
Technologiepark 82 Bus 41
9052 Zwijnaarde

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES
Spain
Net EU contribution
€ 251 971,20
Address
Ctra C-59 Km 12 Torre Marimon
08140 Caldes De Montbui Barcelona

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Region
Este Cataluña Barcelona
Activity type
Other
Other funding
No data
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
Net EU contribution
€ 129 718,80
Address
Via Morego 30
16163 Genova

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Other funding
No data
NUTRITION SCIENCES
Belgium
Net EU contribution
€ 393 930,00
Address
Booiebos 5
9031 Drongen

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
MEDRES-MEDICAL RESEARCH GMBH
Germany
Net EU contribution
€ 130 269,60
Address
Gleueler Strasse 50
50931 Koln

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
CHEMPRECISE CONSULTORIA BIOTECNOLOGIA PRODUTOS FARMACEUTICOS E IMOBILIARIO LDA
Portugal
Net EU contribution
€ 365 104,80
Address
Rua Da Horta Nova 6
2560-654 Torres Vedras

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Centro (PT) Oeste
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data

Partners (10)

ASSOCIAZIONE TOURISM
Italy
Net EU contribution
€ 0,00
Address
Piazza Roma 20
00074 Nemi

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Region
Centro (IT) Lazio Roma
Activity type
Other
Other funding
No data
DES SOLUTIO - SOLUCOES E CONSULTORIA CIENTIFICA LDA
Portugal
Net EU contribution
€ 0,00
Address
Rua Helena Felix 20 2 Recuado
2820 266 Charneca De Caparica

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
INNOSO BV
Netherlands
Net EU contribution
€ 0,00
Address
Ruychrocklaan 68
2597 EP 'S Gravenhage

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Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
PROGREDUM GMBH
Germany
Net EU contribution
€ 0,00
Address
Otterberger Strasse 73
67659 Kaiserslautern

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Rheinland-Pfalz Rheinhessen-Pfalz Kaiserslautern, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 0,00
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
€ 0,00
Address
University Avenue
G12 8QQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Other funding
No data
Faculdade de Farmácia da Universidade de Lisboa
Portugal
Net EU contribution
€ 0,00
Address
Av. Prof. Gama Pinto
1649-003 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
Net EU contribution
€ 0,00
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Other funding
No data
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 0,00
Address
Hofgartenstrasse 8
80539 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
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No data
MEDIZINISCHE UNIVERSITAET WIEN
Austria
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€ 0,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
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Higher or Secondary Education Establishments
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No data