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Cell-free synthetic biology for combinatorial biosensor design

Objective

Recent advances in the field of synthetic biology offer an unprecedented opportunity for next-generation biosensors characterized by programmability, low-cost and by a sensitivity and specificity unmet by conventional sensors. Leveraging the rich toolset of synthetic biology, we can now not only build better biosensors but also analytical tools that can sense and discern complex analyte profiles, such as a panel of biomarkers indicative of a certain disease status. These cell-free biosensors developed within the SYNSENSO research program will be transformative for many domains of research and innovation, ranging from in-vitro diagnostics to health, environmental and bioprocess monitoring. Our ambition is to provide a game change in biosensing by combining cell-free synthetic biology with molecular sensor design.
The SYNSENSO European doctoral network focuses on the construction of novel programmable ligand-responsive elements and the construction of cell-free computing circuits that can integrate molecular signals from those elements. Together the two components will make up the next generation of combinatorial biosensors that can sense signals and compute a response to them. SYNSENSO aims for a modular approach where different responsive elements can be composed with different computing circuits enabling fast construction of suitable sensors for new application domains.
SYNSENSO brings together academic and industry leaders from the fields of synthetic biology, molecular sensor design and DNA nanotechnology. Our industry partners will provide a unique ecosystem for ten doctoral candidates of this network. Together with the external advisory board including experts from medical diagnostics they will work on concrete case studies for clinically relevant analytes. The SYNSENSO training program will empower them to perform world-class research and become academic or industry leaders in this new emerging field at the intersection of synthetic biology and biosensors.

Coordinator

TECHNISCHE UNIVERSITAT DARMSTADT
Net EU contribution
€ 781 617,60
Address
Karolinenplatz 5
64289 Darmstadt
Germany

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (5)

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
Net EU contribution
€ 548 740,80
Address
Groene Loper 3
5612 AE Eindhoven

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
No data
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
Net EU contribution
€ 259 437,60
Address
Via Morego 30
16163 Genova

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Other funding
No data
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Net EU contribution
€ 518 875,20
Address
Via Cracovia 50
00133 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
No data
DYNAMIC BIOSENSORS GMBH
Germany
Net EU contribution
€ 260 539,20
Address
Perchtinger Strasse 8/10
81379 Munich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
ULISSE BIOMED
Italy
Net EU contribution
€ 259 437,60
Address
Via Cavour 20
33100 Udine

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Region
Nord-Est Friuli-Venezia Giulia Udine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data

Partners (8)

Abvance Biotech srl
Spain
Net EU contribution
€ 0,00
Address
Av. Reina Victoria 32
28003 Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
ACCELOPMENT SCHWEIZ AG
Switzerland
Net EU contribution
€ 0,00
Address
Seefeldstrasse 198
8008 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
LENIOBIO GMBH
Germany
Net EU contribution
€ 0,00
Address
Erkrather Strasse 401
40231 Dusseldorf

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG
Germany
Net EU contribution
€ 0,00
Address
Darmstädter Straße 34-36
64673 Zwingenberg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Darmstadt Bergstraße
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
Nuclera Nucleics Ltd
United Kingdom
Net EU contribution
€ 0,00
Address
137 Cambridge Science Park, Milton Road
CB4 0GD Cambridge

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
BIOMERIEUX SA
France
Net EU contribution
€ 0,00
Address
Chemin De L'orme
69280 Marcy L'etoile

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 0,00
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
No data
Department of Biology, University of Naples Federico II
Italy
Net EU contribution
€ 0,00
Address
Via Cinthia 7
80121 Naples

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Region
Sud Campania Napoli
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
No data