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Long-TREC: The Long-Reads Transcriptomics European Consortium. The next generation transcriptome biology revealed by single molecule sequencing technologies

Objective

Thrid-generation, single-molecule long-read sequencing technologies such as Nanopore and Pacbio are revolutionizing transcriptome research and are expected to outcompete short-reads sequencing for gene expression studies. However, technical and bioinformatics challenges exist to the realization of this full potential. In this project, we will train a team of excellent Doctoral Candidates to become the European and world leaders in the field of long reads transcriptome sequencing (lrRNA-seq). The team will address three fundamental aspects of current barriers to the progress that these technologies face. a) Obtaining high-quality sequencing and preprocessed data from improved library preparation protocols and bioinformatics preprocessing methods, b) Establishment of benchmarked analysis pipelines for the application of these approaches to genome annotation and isoform usage analysis both in bulk and single-cell samples, and c) Extension of long reads to multi-omics applications for the study of regulatory biology. Additionally, DC will follow an intensive and comprehensive training program composed of scientific and soft skills training, including activities related to pressing societal challenges such as climate change, diversity and inclusion, and the ethics of science. Students will complement their education through secondments in top European laboratories and Companies as well as through exposure to a network of worldwide experts in the field of RNA research.

Fields of science

Programme(s)

Topic(s)

Call for proposal

HORIZON-MSCA-2021-DN-01

See other projects for this call

Funding Scheme

HORIZON-AG-UN - HORIZON Unit Grant

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Net EU contribution
€ 251 971,20
Address
Calle Serrano 117
28006 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Links
Other funding
No data

Participants (8)

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
Net EU contribution
€ 503 942,40
Address
Carrer Doctor Aiguader 88
08003 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Other funding
No data
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
Net EU contribution
€ 259 437,60
Address
Via Morego 30
16163 Genova

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Links
Other funding
No data
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 282 693,60
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Links
Other funding
No data
BIOBAM BIOINFORMATICS SL
Spain
Net EU contribution
€ 251 971,20
Address
Avenida Peris Y Valero 78-23
46006 Valencia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
No data
STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 293 709,60
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
NACIONALNI INSTITUT ZA BIOLOGIJO
Slovenia
Net EU contribution
€ 242 179,20
Address
Vecna Pot 111
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Research Organisations
Links
Other funding
No data
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 260 539,20
Address
Hofgartenstrasse 8
80539 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Links
Other funding
No data
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 282 693,60
Address
Rue Leblanc 25
75015 Paris 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Links
Other funding
No data

Partners (20)

SB SCIENCE MANAGEMENT UG
Germany
Net EU contribution
No data
Address
Muthesiusstr 11
12163 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
No data
INSTITUTO GULBENKIAN DE CIENCIA
Portugal
Net EU contribution
No data
Address
Rua Da Quinta Grande, 6
2780-156 Oeiras

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
No data
UNIVERSITAT DE VALENCIA
Spain
Net EU contribution
No data
Address
Avenida Blasco Ibanez 13
46010 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
MEDNARODNA PODIPLOMSKA SOLA JOZEFA STEFANA
Slovenia
Net EU contribution
No data
Address
Jamova 39
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
UNIVERSITE COTE D'AZUR
France
Net EU contribution
No data
Address
Grand Chateau 28 Avenue Valrose
06100 Nice

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Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Alpes-Maritimes
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
UNIVERSITY OF EAST ANGLIA
United Kingdom
Net EU contribution
No data
Address
Earlham Road
NR4 7TJ Norwich

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Region
East of England East Anglia Norwich and East Norfolk
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION
Spain
Net EU contribution
No data
Address
Calle Jordi Girona 31
08034 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Other funding
No data
UPPSALA UNIVERSITET
Sweden
Net EU contribution
No data
Address
Von Kraemers Alle 4
751 05 Uppsala

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
Wobble Genomics Limited
United Kingdom
Net EU contribution
No data
Address
Suite 2, Ground Floor Orchard Brae House, 30 Queensferry Road, Edinburgh, United Kingdom
EH4 2HS Edinburgh

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Eastern Scotland Edinburgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
No data
Storm Therapeutics
United Kingdom
Net EU contribution
No data
Address
Babrahm Research Campus
CB22 3AT Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
No data
UNIVERSITY OF FLORIDA
United States
Net EU contribution
No data
Address
Grinter Hall 223
32611 5500 Gainesville

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Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
Joan & Sanford I. Weill Medical College of Cornell University
United States
Net EU contribution
No data
Address
1300 York Avenue
10065-4805 New York

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Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
university of california santa cruz genomics institute
United States
Net EU contribution
No data
Address
1156 High St -- Cbse
95064 Santa Cruz, Ca

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Links
Other funding
No data
Stichting Global Organisation for Bioinformatics Learning, Education and Training
Netherlands
Net EU contribution
No data
Activity type
Other
Links
Other funding
No data
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
Net EU contribution
No data
Address
University Park
NG7 2RD Nottingham

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Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
UNIVERSIDAD POMPEU FABRA
Spain
Net EU contribution
No data
Address
Placa De La Merce, 10-12
08002 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
OXFORD NANOPORE TECHNOLOGIES LTD
United Kingdom
Net EU contribution
No data
Address
Robert Robinson Avenue - Oxford Science Park 4
OX4 4GA Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
No data
EARLHAM INSTITUTE
United Kingdom
Net EU contribution
No data
Address
Norwich Research Park Colney Lane
NR4 7UZ Norwich

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Region
East of England East Anglia Breckland and South Norfolk
Activity type
Research Organisations
Links
Other funding
No data
FREIE UNIVERSITAET BERLIN
Germany
Net EU contribution
No data
Address
Kaiserswerther Strasse 16-18
14195 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data
UNIVERSITE PARIS-SACLAY
France
Net EU contribution
No data
Address
Batiment Breguet - 3 Rue Joliot Curie
91190 Gif-sur-yvette

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Higher or Secondary Education Establishments
Links
Other funding
No data

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EC signature date: 14 July 2022
Last update: 12 September 2022
Record number: 241065

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Permalink: https://cordis.europa.eu/project/id/101072892

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