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Quality Control of the Mitochondrial Gene Expression System in Health and Disease

Objective

Mitochondria produce most of the energy the body acquires through food, and are thus pivotal players in cellular metabolism. Central to mitochondrial biology is the DNA in the organelle (mtDNA): its maintenance, correct RNA processing, and efficient translation are all essential and must be coordinated to ensure proper mitochondrial function and cellular physiology. Defective maintenance or expression of mtDNA alters energy and nutrient metabolism, which are increasingly recognized to impact medical disciplines, ranging from hundreds of genetic disorders to neurodegeneration, immunology, transmissible disease, cancer and ageing. A deep understanding of the mitochondrial gene expression system and new methods are urgently needed to develop treatments for the full panoply of mitochondrial disorders that feature mtDNA perturbation.
MITGEST will unite world-class academic excellence in mtDNA maintenance and expression with private sector expertise in nucleic acid chemistry and the development of mitochondrial therapeutics to address this urgent need. As the first research training programme in this field to take a fully integrated approach, our 10 doctoral candidates (DC) will elucidate how mtDNA is maintained and expressed and support the development of new methods to analyse RNA and DNA metabolism in mitochondria. These advances will complement and facilitate/enhance innovative treatment strategies and experimental medicine studies designed to mitigate mitochondrial dysfunction in a range of human diseases.
Our network of 7 beneficiaries and 12 associated partners from 8 European countries and Israel builds on proven collaborations and establishes new partnerships to deliver intersectoral and multidisciplinary scientific and transferable skills training to our 11 PhD students to generate the next generation of highly-skilled scientists able to exploit the latest advances in mitochondrial biology and medicine.

Coordinator

UNIVERSITA DEGLI STUDI DI UDINE
Net EU contribution
€ 518 875,20
Address
Via Palladio 8
33100 Udine
Italy

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Region
Nord-Est Friuli-Venezia Giulia Udine
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (6)

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 548 740,80
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
No data
INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 226 512,00
Address
Pawinskiego 5a
02 106 Warszawa

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Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Research Organisations
Other funding
No data
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 293 709,60
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
No data
ASOCIACION INSTITUTO BIODONOSTIA
Spain
Net EU contribution
€ 503 942,40
Address
Paseo Dr. Beguiristain S/n
20014 Donostia-san Sebastian

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Other funding
No data
BASECLICK GMBH
Germany
Net EU contribution
€ 260 539,20
Address
Floriansbogen 2-4
82061 Neuried

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Region
Bayern Oberbayern München, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
MINOVIA THERAPEUTICS
Israel
Net EU contribution
€ 271 432,80
Address
Hasadna 3
3902603 Tirat Hacarmel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data

Partners (12)

4BASEBIO SL
Spain
Net EU contribution
€ 0,00
Address
Faraday, 7 Edif Claid
28049 Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
No data
ACCELOPMENT SCHWEIZ AG
Switzerland
Net EU contribution
€ 0,00
Address
Seefeldstrasse 198
8008 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
AGILENT TECHNOLOGIES ITALIA SPA
Italy
Net EU contribution
€ 0,00
Address
Via Piero Gobetti 2c
20063 Cernusco Sul Naviglio

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 0,00
Address
Noskowskiego 12-14
61 704 Poznan

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Region
Makroregion północno-zachodni Wielkopolskie Miasto Poznań
Activity type
Research Organisations
Other funding
No data
LUMICKS BV
Netherlands
Net EU contribution
€ 0,00
Address
Paalbergweg 3
1105 AG Amsterdam

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
Predica Diagnostics BV
Netherlands
Net EU contribution
€ 0,00
Address
Reinier Postlaan 2
6525 GC Nijmegen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 0,00
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
Net EU contribution
€ 0,00
Address
Strada Nuova 65
27100 Pavia

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Region
Nord-Ovest Lombardia Pavia
Activity type
Higher or Secondary Education Establishments
Other funding
No data
CAREERS RESEARCH AND ADVISORY CENTRE (CRAC) LIMITED (THE)
United Kingdom
Net EU contribution
€ 0,00
Address
22 Signet Court Swann Road
CB5 8LA Cambridge

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England East Anglia Cambridgeshire CC
Activity type
Other
Other funding
No data
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 0,00
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
No data
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Net EU contribution
€ 0,00
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain
Net EU contribution
€ 0,00
Address
Barrio Sarriena S N
48940 Leioa

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Region
Noreste País Vasco Bizkaia
Activity type
Higher or Secondary Education Establishments
Other funding
No data