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High-resolution cryo-EM structures of the human and yeast Sin3 histone deacetylase complexes

Project description

Using cryo-electron microscopy to solve the 3D structure of histone deacetylase complexes

Histone deacetylase (HDAC) complexes contain enzymes that modify histones, repressing transcription processes in eukaryotes. Disruption of HDAC functions results in various diseases, including cancer, inflammatory diseases and neurological disorders. The absence of high-resolution 3D structures for HDAC complexes prevents the development of novel drugs that target specific complex subunits to reprogramme particular HDAC biological functions. Funded by the Marie Skłodowska-Curie Actions programme, the HDACbyCRYOEM project aims to utilise cryo-electron microscopy (cryo-EM) to solve the 3D structures of human and yeast HDAC complexes at near-atomic resolution. HDAC complexes have changed very little over evolutionary time and are formed by a limited number of proteins, making them an ideal target for single-particle cryo-EM.


Net EU contribution
€ 191 760,00
Oude Markt 13
3000 Leuven

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Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Other funding
No data