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Structural determination and dynamics of the mitochondrial import protein (MIM) by cryo-EM and magic-angle-spinning (MAS) nuclear magnetic resonance (NMR)

Project description

Studying the mechanisms of import and insertion of the proteins into mitochondrial membrane

Mitochondria are cell energy factories involved in aging and cell death. Their functions require many different proteins synthesized outside the organelle to be delivered and inserted into the right compartment. Funded by the Marie Skłodowska-Curie Actions programme, the MitoMemInsert project will focus on the mechanisms of α-helical membrane protein insertion into the mitochondrial outer membrane and on the structure of the insertase. The study will employ cryo-electron microscopy combined with magic-angle-spinning nuclear magnetic resonance spectroscopy to determine the atomic-resolution structure of mitochondrial import protein (MIM) in yeast. The results will uncover how the MIM complexes engage polypeptides to form precursor proteins for insertion into the membrane.

Coordinator

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Net EU contribution
€ 199 440,96
Address
Am Campus 1
3400 Klosterneuburg
Austria

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Region
Niederösterreich Wiener Umland/Nordteil
Activity type
Higher or Secondary Education Establishments
Other funding
No data