Project description
Characterisation of nucleic acid quadruplex−duplex hybrids and their targeting by drug-like ligands
Nucleic acids are polymorphic, and guanine-rich nucleic acid sequences can form G-quadruplex (G4) structures in addition to classic duplexes. The formation of G4 structures was shown in vitro in solutions and cells, where they presented attractive targets for small molecules. Recent studies suggest that G4 folding may differ in the cellular environment due to the limitation of the components. Funded by the Marie Skłodowska-Curie Actions programme, the QDHassay project aims to develop specific G4 drugs targeting G4 quadruplex−duplex hybrids (QDH). The project will use low- and high-resolution spectroscopy as well as ligand screening based on mass spectrometry to characterise ligand−QDH interaction. The final goal is to develop an in-cell nucleic acid folding spectroscopy analysis method and a ligand screening assay inside the cellular system.
Fields of science
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
MSCA-PF - MSCA-PF
Coordinator
601 77 Brno
Czechia
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Partners (1)
60323 Frankfurt Am Main
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