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Improving quality of life of advanced pancreatic cancer patients through an AI-guided multimodal intervention, combining pain and cachexia management, nutrition, and physical activity

Objective

Pancreatic cancer has the lowest survival rate amongst other cancers and is responsible for 95,000 deaths every year in the EU. Its treatment is usually palliative, aiming at slowing tumour progression and at symptom management.
The main hypothesis of RELEVIUM is that quality of life (QoL) of advanced pancreatic cancer patients can be significantly improved by reducing pain and cachexia through highly personalised nutrition, physical activity, and pain management strategies, in addition to chemotherapy treatment. To achieve this, RELEVIUM will empower patients with digital tools that facilitate patient-doctor communication and enable them to self-manage their disease. RELEVIUM will use (i) a multi-sensor smartwatch and an innovative remote ultrasound patch, (ii) AI algorithms for continuous remote monitoring of pain and sarcopenia, as well as for decision support, and (iii) patient and caregiver applications. Combined, these tools will provide a stream of evidence on symptom progression and will enable physicians to apply personalised care plans.
RELEVIUM brings together an interdisciplinary team of experts and will also involve patients and their caregivers in an iterative co-creation process. The project will initially conduct a feasibility and data collection study (RELEVIUM-FDC, n=130). The study aims at optimizing patient adherence and compliance, and at collecting data for the development of the intervention. A five-centre randomized clinical trial (RELEVIUM-RCT) will then evaluate the efficacy of the proposed personalised care plans for advanced pancreatic cancer patients (n=132) in terms of their QoL. Several secondary outcomes will be investigated, such as the cost-effectiveness of the intervention, its potential in increasing health equity and in relieving the stress burden on the patient families.
The study outcomes will result in recommendations for integrating remote monitoring and improving QoL outcomes in palliative care for advanced pancreatic cancer

Coordinator

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Net EU contribution
€ 750 000,00
Address
Langenbeckstrasse 1
55131 Mainz
Germany

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (17)

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany
Net EU contribution
€ 500 000,00
Address
Saarstrasse 21
55122 Mainz

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Greece
Net EU contribution
€ 412 500,00
Address
Charilaou Thermi Road 6 Km
57001 Thermi Thessaloniki

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Region
Θεσσαλονίκη Κεντρική Μακεδονία Βόρεια Ελλάδα
Activity type
Research Organisations
Other funding
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 308 750,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
CHAROKOPEIO PANEPISTIMIO
Greece
Net EU contribution
€ 500 000,00
Address
Eleftheriou Venizelou 70
176 71 Athina

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Region
Νότιος Τομέας Αθηνών Aττική Αττική
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EXUS SOFTWARE MONOPROSOPI ETAIRIA PERIORISMENIS EVTHINIS
Greece
Net EU contribution
€ 475 000,00
Address
Theanous 15
118 54 Athens

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
AINIGMA TECHNOLOGIES
Belgium
Net EU contribution
€ 350 000,00
Address
Kapeldreef 60
3001 Leuven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
MCS DATALABS
Germany
Net EU contribution
€ 417 812,00
Address
Hubertusallee 42
14193 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,50
FUTURO PERFECTO INNOVACION SL
Spain
Net EU contribution
€ 223 875,00
Address
Primavera De Praga 11
28030 Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
EUROPEAN CANCER PATIENT COALITION
Belgium
Net EU contribution
€ 112 500,00
Address
Avenue Des Arts 6
1210 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Other funding
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 200 000,00
Address
Rue D Ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
THE HEALTH CORPORATION - RAMBAM
Israel
Net EU contribution
€ 215 000,00
SIHTASUTUS POHJA-EESTI REGIONAALHAIGLA
Estonia
Net EU contribution
€ 150 000,00
Address
J Sutiste Tee 19
13419 Tallinn

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Region
Eesti Eesti Põhja-Eesti
Activity type
Other
Other funding
€ 0,00
INSTITUT JULES BORDET ASBL
Belgium
Net EU contribution
€ 150 000,00
Address
Rue Meylemeersch, 90
1070 Anderlecht

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
DBC EUROPE
Belgium
Net EU contribution
€ 179 375,00
Address
Rond Point Robert Schuman 6
1040 Bruxelles

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
PULSIFY MEDICAL BV
Belgium
Net EU contribution
€ 450 000,00
Address
Philipssite 5
3001 Leuven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CSI CENTER FOR SOCIAL INNOVATION LTD
Cyprus
Net EU contribution
€ 101 875,00
Address
62 Rigainis Street, 1st Floor
1010 Nicosia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Κύπρος Κύπρος Κύπρος
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
ROZENBAUM KONSULTING
Bulgaria
Net EU contribution
€ 500 625,00
Address
Ul 6ti Septemvri 13 B
1000 Sofia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Югозападна и Южна централна България Югозападен София (столица)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00