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Pain relief in palliative care of cancer using home-based neuromodulation and predictive biomarkers

Objective

More than 50% of cancer patients develop pain before death: 80% can be treated with drugs, but 20% show a low response or have serious adverse effects. Although non-pharmacological interventions such as neurosurgical procedures have been tested, these alternatives are not a preferred option to treat cancer pain due to their high cost, risk, invasiveness and not always proven efficacy.
PAINLESS addresses a core component of pain relief, by using an innovative, evidence-based approach. The objective is to adapt and implement a novel, cost-effective, home-based intervention based on neuromodulation to reduce pain and improve quality of life of cancer patients with chronic pain. On the assumption that treatment of chronic pain can benefit from research on the brain mechanisms of pain, we will first attempt to improve our understanding of the role of central pain modulation.
The project will be organized in 3 studies: 1) A cohort, longitudinal study (n=450) to explore whether the biomarkers of central pain modulation mechanisms can be predictive of the future occurrence of chronic pain in cancer patients; 2) A cross-sectional study to characterize and stratify cancer patients with vs. without chronic pain (750 patients with the proposed biomarkers and taking into account a number of moderator variables); 3) A pilot study (n=450) to assess the feasibility an efficacy of at-home delivery of transcranial low intensity electric stimulation (tES) for the palliative care of cancer patients suffering from pain
PAINLESS will develop a customized web portal to share knowledge and to improve management of the patients; perform techno-economic analyses and Health Technology Assessment of the solution; analyze the possibilities of implementation in different European healthcare systems and results exploitation; and undertake an ambitious dissemination and communication strategy. We will also propose a wide range of measures to ensure compliance with the highest ethical standars.

Coordinator

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Net EU contribution
€ 892 898,00
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Spain

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Region
Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,75

Participants (17)

SERVIZO GALEGO DE SAUDE
Spain
Net EU contribution
€ 174 840,00
Address
Edificio Administrativo San Lázaro
15703 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACION BIOMEDICA GALICIA SUR
Spain
Net EU contribution
€ 281 272,00
Address
Hospital Alvaro Cunqueiro, Bloque Tecnico - Planta Estrada Clara Campoamor, 341
36312 Vigo

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Region
Galicia Pontevedra
Activity type
Research Organisations
Other funding
€ 0,50
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
Spain
Net EU contribution
€ 437 158,00
Address
Travesa Da Choupana
15706 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Research Organisations
Other funding
€ 0,75
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
Net EU contribution
€ 542 023,00
Address
Robert-koch-strasse 40
37075 Goettingen

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Region
Niedersachsen Braunschweig Göttingen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,75
AALBORG UNIVERSITET
Denmark
Net EU contribution
€ 227 625,00
Address
Fredrik Bajers Vej 7k
9220 Aalborg

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Region
Danmark Nordjylland Nordjylland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUNDATIA HOSPICE CASA SPERANTEI
Romania
Net EU contribution
€ 305 000,00
Address
Strada Sitei 17a
500074 Brasov

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Region
Macroregiunea Unu Centru Braşov
Activity type
Research Organisations
Other funding
€ 0,00
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Net EU contribution
€ 500 500,00
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 75,00
INSTITUTUL ONCOLOGIC PROF. DR. ALEXANDRU TRESTIOREANU BUCURESTI
Romania
Net EU contribution
€ 377 000,00
Address
Soseaua Fundeni 252
022328 Bucharest

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Region
Macroregiunea Trei Bucureşti-Ilfov Bucureşti
Activity type
Research Organisations
Other funding
€ 0,00
INSTITUTO PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL, EPE
Portugal
Net EU contribution
€ 341 750,00
Address
Rua Antonio Bernardino Almeida
4200-072 Porto

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
EUROPEAN ASSOCIATION FOR PALLIATIVE CARE
Belgium
Net EU contribution
€ 173 250,00
Address
Airportlaan 10
1800 Vilvoorde

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde
Activity type
Other
Other funding
€ 0,00
EUROPEAN CANCER PATIENT COALITION
Belgium
Net EU contribution
€ 100 125,00
Address
Avenue Des Arts 6
1210 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Other funding
€ 0,00
NEUROCONN GMBH
Germany
Net EU contribution
€ 266 062,00
Address
Albert-einstein-strasse 3
98693 Ilmenau

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Thüringen Thüringen Ilm-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,50
BETTHERA S.R.O.
Czechia
Net EU contribution
€ 255 625,00
Address
Medkova 1590/32
500 02 Hradec Kralove

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Severovýchod Královéhradecký kraj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
SOFTWARE IMAGINATION & VISION SRL
Romania
Net EU contribution
€ 489 500,00
Address
Soseaua Bucuresti-ploiesti 73-81 Complex Victoria Corp Cladire C4 Etaj 2
013685 Bucuresti

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Macroregiunea Trei Bucureşti-Ilfov Bucureşti
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
QST LAB
France
Net EU contribution
€ 244 250,00
Address
21 Rue Becquerel Cnrs Strasbourg
67087 Strasbourg

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Region
Grand Est Alsace Bas-Rhin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Mentalab GmbH
Germany
Net EU contribution
€ 242 062,00
Address
Weinstr. 4
80333 Munich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,50
ASSOCIATION EUROPEENNE DES LIGUES CONTRE LE CANCER ASBL
Belgium
Net EU contribution
€ 101 305,00
Address
Chaussee De Louvain 479
1030 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Other funding
€ 2 000,00

Partners (1)

Ente Ospedaliero Cantonale
Switzerland
Net EU contribution
€ 0,00
Address
Vialle Officina 3
CH-6500 Bellinzona

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Region
Schweiz/Suisse/Svizzera Ticino Ticino
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00