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Gene Environment interactions in Mental health trajectories of Youth

Objective

Youth mental health is heavily burdened, with life-long enduring impact on European citizens and societies. Trajectories of mental health and illness in young people are assumed to be determined by interplay between genetic, epigenetic, and environmental risk impacting during development. However, direct evidence for this is sparse and scientific progress is challenged. We recently initiated substantial advances enabling us to create necessary breakthroughs at the most pressing needs and challenges. Aiming to significantly reduce mental suffering and illness among European youth within the next 5-10 years, we will provide 1) the world?s first, evidence-based knowledge base of functional (epi)genomics of the developing post-natal human brain in direct relation to developmental trajectories of trans-syndromal phenotypes of mental illness, providing improved risk markers and actionable biological targets, 2) reliable predictive models, while identifying gene-environment interplay, as well as actionable markers of trajectories of mental (ill)health in young people through the use of Artificial Intelligence (AI)-based and inference-based analyses of unprecedented sets of longitudinal general population datasets, 3) the first comprehensive, validated set of evidence-based behavioural, environmental, biological, and psychological-informed instruments for the robust quantitative clinical assessment of mental health for help-seeking young people aged 12-24 years, harmonised across European clinical settings, and 4) youth- and clinician-empowering AI-driven instruments for early (self)detection, prediction and monitoring of mental ill-health trajectories in youth. Our multidisciplinary consortium is uniquely equipped and positioned to enforce the necessary breakthroughs for significant reduction of mental illness and suffering of young people, and to translate our findings into clinical innovation and life-long impact in Europe and beyond.

Coordinator

UNIVERSITEIT MAASTRICHT
Net EU contribution
€ 2 386 512,00
Address
Minderbroedersberg 4
6200 MD Maastricht
Netherlands

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 386 512,00

Participants (12)

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
Net EU contribution
€ 449 694,00
Address
St Stephen's Green 123
2 Dublin

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Region
Ireland Northern and Western Border
Activity type
Higher or Secondary Education Establishments
Other funding
€ 449 694,00
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 400 000,00
Address
Hofgartenstrasse 8
80539 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 400 000,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 918 500,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 918 500,00
UNIVERSITAT DE BARCELONA
Spain
Net EU contribution
€ 708 125,00
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Other funding
€ 708 125,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 666 945,00
Address
Belfield
4 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 666 945,00
Stichting Hogeschool Utrecht
Netherlands
Net EU contribution
€ 412 950,00
Address
Padualaan 99
3584 CH Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 412 950,00
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
Net EU contribution
€ 175 000,00
Address
Carrer Doctor Aiguader 88
08003 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 175 000,00
TARTU ULIKOOL
Estonia
Net EU contribution
€ 347 000,00
Address
Ulikooli 18
51005 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Other funding
€ 347 000,00
KLINIKA ZA NEUROLOGIJU I PSIHIJATRIJU ZA DECU I OMLADINU
Serbia
Net EU contribution
€ 293 936,00
Address
Dr Subotic 6a
11000 Belgrade

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Region
Србија - север Београдски регион Београдска област
Activity type
Higher or Secondary Education Establishments
Other funding
€ 293 936,00
AB.ACUS SRL
Italy
Net EU contribution
€ 360 625,00
Address
Via Francesco Caracciolo 77
20155 Milano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 360 625,00
SVEUCILISTE U SPLITU MEDICINSKI FAKULTET
Croatia
Net EU contribution
€ 314 718,00
Address
Soltanska Ulica 2
21 000 Split

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Region
Hrvatska Jadranska Hrvatska Splitsko-dalmatinska županija
Activity type
Higher or Secondary Education Establishments
Other funding
€ 314 718,00
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON
Spain
Net EU contribution
€ 673 975,00
Address
Calle Doctor Esquerdo 46
28007 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Other
Other funding
€ 673 975,00

Partners (5)

THE UNIVERSITY OF QUEENSLAND
Australia
Net EU contribution
€ 0,00
Other funding
€ 0,00
THE UNIVERSITY OF EXETER
United Kingdom
Net EU contribution
€ 0,00
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter

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Region
South West (England) Devon Devon CC
Activity type
Higher or Secondary Education Establishments
Other funding
No data
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 0,00
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
No data
CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 0,00
Address
Newport Road 30 36
CF24 0DE Cardiff

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Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 0,00
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
No data