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Development and validation of a quantitative point-of-care test for the measurement of severity biomarkers to improve risk stratification of fever syndromes and enhance child survival

Objective

"Fever is the leading reason to seek healthcare globally, with over 1 billion cases of febrile illness occurring in children annually. The vast majority of infections are uncomplicated and self-limited and can be treated conservatively. A few (<1%) are life-threatening but are often challenging to identify early in the course of illness. Our project challenges the current status quo and inefficiencies of triaging practices. We propose to develop and validate a rapid triaging tool to determine, objectively, quantitatively and with high precision those patients at risk of dying, so as to prioritize their care.
The breakthrough solution lies in the ENDOTHELIUM, a newly recognized in vivo biosensor, which plays a critical role in our defense against pathogens. Endothelial cell activation and subsequent loss of integrity is a common pathway of injury in several life-threatening infections, including sepsis, malaria, or even COVID-19. Measuring specific mediators of this pathway (sTREM-1, Ang2, etc.) at first clinical presentation can reliably identify individuals at risk of dying, irrespective of the disease causing the fever, and more robustly than previously known predictors such as clinical algorithms or ""classic"" biomarkers. Importantly, these pathways are also ""druggable"", thus allowing the testing or re-purposing of specific interventions to improve outcome.
We will design and produce a RTT (glucometer-like) that quantitatively measures the two markers with best predictive performance (sTREM-1 and Ang2). We will then incorporate it into 2 clinical trials (to be done in Mozambique, Gabon and Ethiopia) to 1) verify the improved performance of the proposed PoC RTT in risk-stratifying and predicting mortality among paediatric patients when compared to standard of care, and 2) test whether a specific intervention (nutritional supplementation of L-Citrulline), guided by biomarker results, improves (vs. placebo) long-term outcomes and survival after hospital discharge.
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Coordinator

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Net EU contribution
€ 2 124 387,00
Address
C Rossello 132 Planta 05
08036 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,50

Participants (8)

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 349 058,00
Address
Geschwister-scholl-platz
72074 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,75
BIOECLOSION SL
Spain
Net EU contribution
€ 142 225,00
Address
Av Can Domenech,edif.eureka, Campus Universitat Cerdanyola Del Valles08193
08193 Bellaterra

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FUNDACAO MANHICA
Mozambique
Net EU contribution
€ 1 778 025,00
Address
Rua 12 Bairro Cambeve Distrito Da Manhica
1929 Vila Da Manhica Maputo

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Activity type
Research Organisations
Other funding
€ 0,00
Centre de Recherches Medicales de Lambaréné
Gabon
Net EU contribution
€ 1 142 687,00
ASPHALION SL
Spain
Net EU contribution
€ 127 500,00
Address
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
Net EU contribution
€ 28 625,00
Address
Piazza Sant Onofrio 4
00165 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITAT AUTONOMA DE BARCELONA
Spain
Net EU contribution
€ 347 290,00
Address
Edif A Campus De La Uab Bellaterra Cerdanyola V
08193 Cerdanyola Del Valles

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUNDACIO EURECAT
Spain
Net EU contribution
€ 495 875,00
Address
Avenida Universitat Autonoma 23
08290 Cerdanyola Del Valles (Barcelona)

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00

Partners (3)

UNIVERSITY HEALTH NETWORK
Canada
Net EU contribution
No data
Address
190 Elizabeth Street
M5G2C4 Toronto

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Activity type
Research Organisations
Other funding
No data
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
Net EU contribution
No data
Address
Keppel Street
WC1E 7HT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
No data
LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE
United Kingdom
Net EU contribution
No data
Address
Houghton Street 1
WC2A 2AE London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
No data