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A holistic approach in patient management and epidemic surveillance through convergence of diagnostic technologies, capacity building and stakeholder engagement

Objective

Research on Poverty-Related Diseases (PRDs) in sub-Saharan Africa suffers from major technological and non-technological challenges that prevent high quality healthcare to reach many areas. Not only their performance, but also the affordability, manufacturability, suitability for Low- and Middle-Income Countries (LMICs) and deployment of the (few) available diagnostics are main barriers to ensure good quality of healthcare in sub-Saharan Africa. The HoliCare project aims to tackle such challenges from a holistic perspective, by bridging the gap between technological excellence, available infrastructures, capacity, and local uptake of new technologies. We have chosen to work with lower respiratory infections as a blueprint for our new approach due to their huge clinical and socioeconomic impact, and relevance to the SARS-CoV-2 pandemic. Technology-wise, we propose a 2-tiered, digitally interfaced diagnostic approach that will start in the field using multiplexed lateral flow tests for rapid screening and triage, followed by a referral to a hospital (when needed) and a follow-up detailed diagnosis using a POC-Instrument performing simultaneous nucleic acid amplification (LAMP) for pathogen identification and immunoassays for host biomarker quantitation. Digital and manufacturing infrastructures will encompass these technology innovations to ensure future local product development. Quality controlled biobanks will be developed for executing reliable clinical studies. Training and human capital investment will be achieved by focussed and high-level training activities. Adoption and implementation activities will pave the way for the proposed diagnostic solutions to be successfully deployed, fitting the purpose of the local populations. Our developments will be scalable, adaptable and transferrable to other diseases and national (eco) systems, aiming to contribute to the improvement of healthcare delivery in sub-Saharan Africa.

Coordinator

KUNGLIGA TEKNISKA HOEGSKOLAN
Net EU contribution
€ 799 717,50
Address
Brinellvagen 8
100 44 Stockholm
Sweden

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 799 717,50

Participants (10)

HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV
Germany
Net EU contribution
€ 402 035,00
Address
Wilhelm Schickard Strasse 10
78052 Villingen Schwenning

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Region
Baden-Württemberg Freiburg Schwarzwald-Baar-Kreis
Activity type
Research Organisations
Other funding
€ 402 035,00
MAST DIAGNOSTICA GMBH
Germany
Net EU contribution
€ 430 000,00
Address
Feldstrasse 20
23858 Reinfeld

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schleswig-Holstein Schleswig-Holstein Stormarn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 430 000,00
BLUMORPHO
France
Net EU contribution
€ 455 000,00
Address
38 Rue Jean Mermoz
75008 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 455 000,00
INSTITUT PASTEUR DE DAKAR
Senegal
Net EU contribution
€ 759 060,00
Other funding
€ 759 060,00
MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Uganda
Net EU contribution
€ 428 750,00
Address
Kabale Road Plot 10 18
256 Mbarara

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 428 750,00
ARMAUER HANSEN RESEARCH INSTIUTE
Ethiopia
Net EU contribution
€ 447 845,00
Address
Jimma Road Alert Compound
1005 Addis Ababa

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Activity type
Research Organisations
Other funding
€ 447 845,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 592 612,50
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 592 612,50
STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 554 003,50
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 554 003,50
MAKERERE UNIVERSITY
Uganda
Net EU contribution
€ 500 000,00
Address
Main Campus
256 Kampala

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 500 000,00
ISTOC OY
Finland
Net EU contribution
€ 488 750,00
Address
Rautatienkatu 16 C 31
90100 Oulu

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 488 750,00

Partners (3)

TEESSIDE UNIVERSITY
United Kingdom
Net EU contribution
No data
Address
Borough Road
TS1 3BA Middlesbrough

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Region
North East (England) Tees Valley and Durham South Teesside
Activity type
Higher or Secondary Education Establishments
Other funding
No data
MOLOGIC LTD
United Kingdom
Net EU contribution
No data
Address
Bedford Technology Park Thurleigh
MK44 2YP Bedford

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England Bedfordshire and Hertfordshire Bedford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
MAC Clinical Research 1 Limited
United Kingdom
Net EU contribution
No data
Address
Faraday Way, 1
FY2 0JH Blackpool

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
North West (England) Lancashire Blackpool
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data