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Training the next-generation of European GLIOblastoma (translational) researchers, to RESOLVE precision targeting of the brain tumour microenvironment

Objective

Isocitrate dehydrogenase wildtype (IDHwt) glioblastoma (GBM) is the most frequent, aggressive and lethal brain tumour. It has a universally fatal prognosis with 85% of patients dying within two years. Effective precision medicine therapies are thus urgently required. This can only be achieved by focused multi-sectoral collaborations in innovative research disciplines. Overall, GLIORESOLVE will exploit the intractability of GBM to address European applied biomedical research training needs and will train 10 innovative, entrepreneurial doctoral researchers (DRs). The research objectives of GLIORESOLVE are i) to extend immunotherapy options to IDHwt GBM patients and identify novel tumour microenvironment (TME) subtype-specific therapeutic targets, (ii) develop and optimise state of the art pre-clinical models that recapitulate GBM TME-subtypes and (iii) test novel rationally selected (available) drugs / drug combinations for precision treatment of IDHwt GBM based on TME subtype assignment. Cumulatively, the programme seeks to generate sufficient data to support a post-project Phase 2 clinical trial. The consortium brings together leading European academics, clinicians, private sector and not-for-profit partners, and incorporates disruptive research methods including multi-omics, ex-vivo ‘tumour-on-a-chip’ assay development, computational modelling and systems biology. Overall GLIORESOLVE provides a comprehensive translational research strategy that goes significantly beyond the current state-of-the-art in neuro-oncology, to establish a new TME-targeting precision medicine platform for this incurable disease. The GLIORESOLVE network addresses current needs in academia and the private sector to train doctoral researchers in an environment that spans multiple disciplines. Thus, GLIORESOLVE DRs will be able to navigate confidently between clinical, academic and private sector environments to progress applied research findings towards improved patient outcomes.

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Net EU contribution
€ 286 488,00
Address
St Stephen's Green 123
2 Dublin
Ireland

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Region
Ireland Northern and Western Border
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (9)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 262 620,00
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Other funding
No data
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 274 370,40
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
No data
VIB VZW
Belgium
Net EU contribution
€ 262 620,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
No data
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
Net EU contribution
€ 282 693,60
Address
Boulevard De L'hopital 47
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
No data
LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
Net EU contribution
€ 262 620,00
Address
1a Rue Rue Thomas Edison
1445 Strassen

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Research Organisations
Other funding
No data
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
Net EU contribution
€ 260 539,20
Address
Seminarstrasse 2
69117 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
No data
MIMETAS BV
Netherlands
Net EU contribution
€ 274 370,40
Address
De Limes 7
2342 DH Oegstgeest

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
GENEXPLAIN GMBH
Germany
Net EU contribution
€ 260 539,20
Address
Am Exer 19 B
38302 Wolfenbuttel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Braunschweig Wolfenbüttel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
BAYER AKTIENGESELLSCHAFT
Germany
Net EU contribution
€ 260 539,20
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen

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Region
Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data

Partners (11)

Arjuna Therapeutics S.L.
Spain
Net EU contribution
€ 0,00
Address
Rúa Da Xesta 78, A2, Polígono Industrial “Novo Milladoiro”
15895 Ames (A Coruña)

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Galicia A Coruña
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
BRIGHAM INC
United States
Net EU contribution
€ 0,00
Other funding
No data
CARTHERA
France
Net EU contribution
€ 0,00
Address
47 Boulevard De L'hopital
75013 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
LABORATOIRE NATIONAL DE SANTE
Luxembourg
Net EU contribution
€ 0,00
Address
1 Rue Louis Rech
3555 Dudelange

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
No data
OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 0,00
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Other funding
No data
MILTENYI BIOTEC BV & CO KG
Germany
Net EU contribution
€ 0,00
Address
Friedrich Ebert Strasse 68
51429 Bergisch Gladbach

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Region
Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
SB SCIENCE MANAGEMENT UG
Germany
Net EU contribution
€ 0,00
Address
Muthesiusstr 11
12163 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
International Brain Tumour Alliance
United Kingdom
Net EU contribution
€ 0,00
Address
C/o Hamlins Llp, Roxburghe House, Regent Street 273 - 287
W1B 2AD London

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Region
London Inner London — West Westminster
Activity type
Other
Other funding
No data
UNIVERSITE DU LUXEMBOURG
Luxembourg
Net EU contribution
€ 0,00
Address
2 Avenue De L'universite
4365 Esch-sur-alzette

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Higher or Secondary Education Establishments
Other funding
No data
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 0,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
No data
SORBONNE UNIVERSITE
France
Net EU contribution
€ 0,00
Address
21 Rue De L'ecole De Medecine
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Other funding
No data