Objective
Haematological diseases (HDs) are a large group of disorders resulting from quantitative or qualitative abnormalities of blood cells, lymphoid organs and coagulation factors. Despite most of them (~74%) are rare, the overall number of HD affected patients worldwide is important, placing a considerable economic burden on healthcare systems and societies. Despite the existence of several collaborative research groups at national and EU level, current clinical approaches are often ineffective, particularly for rarest conditions, due to the relatively low number of patients per disease and the high number of unconnected clinical entities.
SYNTHEMA aims to establish a cross-border data hub where to develop and validate innovative AI-based techniques for clinical data anonymisation and synthetic data generation (SDG), to tackle the scarcity and fragmentation of data and widen the basis for GDPR-compliant research in RHDs. The project will focus on two representative RHD use cases: sickle-cell disease (SCD) and acute myeloid leukaemia (AML).
SYNTHEMA will develop a federated learning (FL) infrastructure, equipped with secure multiparty computation (SMPC) and differential privacy (DF) protocols, connecting clinical centres bringing standardised, interoperable multimodal datasets and computing centres from academia and SME. This framework will be utilised to train the developed algorithms and perform SMPC-based global model aggregation in a privacy-preserving fashion. The resulting data will be validated for their clinical value, statistical utility and residual privacy risks. The project will develop legal and ethical frameworks to guarantee privacy by-design in the collection and processing of health-related personal data and attain an ethics-wise algorithm co-creation. Project outcomes, including pipelines, standards and data, will be made openly available to stakeholders in the healthcare, academia and industry field, and contribute to existing rare disease registries
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
28040 Madrid
Spain
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Participants (14)
00138 Roma
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1040 Wien
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08860 Castelldefel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
40126 Bologna
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20009 Donostia San Sebastian
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1853 Strombeek-bever
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08035 Barcelona
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20100 Rozzano (Mi)
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3584 CX Utrecht
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75000 Paris
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10117 Berlin
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1070 313 Lisboa
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35122 Padova
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1253 Luxembourg
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Partners (1)
SO17 1BJ Southampton
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