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Synthetic generation of hematological data over federated computing frameworks

Objective

Haematological diseases (HDs) are a large group of disorders resulting from quantitative or qualitative abnormalities of blood cells, lymphoid organs and coagulation factors. Despite most of them (~74%) are rare, the overall number of HD affected patients worldwide is important, placing a considerable economic burden on healthcare systems and societies. Despite the existence of several collaborative research groups at national and EU level, current clinical approaches are often ineffective, particularly for rarest conditions, due to the relatively low number of patients per disease and the high number of unconnected clinical entities.
SYNTHEMA aims to establish a cross-border data hub where to develop and validate innovative AI-based techniques for clinical data anonymisation and synthetic data generation (SDG), to tackle the scarcity and fragmentation of data and widen the basis for GDPR-compliant research in RHDs. The project will focus on two representative RHD use cases: sickle-cell disease (SCD) and acute myeloid leukaemia (AML).
SYNTHEMA will develop a federated learning (FL) infrastructure, equipped with secure multiparty computation (SMPC) and differential privacy (DF) protocols, connecting clinical centres bringing standardised, interoperable multimodal datasets and computing centres from academia and SME. This framework will be utilised to train the developed algorithms and perform SMPC-based global model aggregation in a privacy-preserving fashion. The resulting data will be validated for their clinical value, statistical utility and residual privacy risks. The project will develop legal and ethical frameworks to guarantee privacy by-design in the collection and processing of health-related personal data and attain an ethics-wise algorithm co-creation. Project outcomes, including pipelines, standards and data, will be made openly available to stakeholders in the healthcare, academia and industry field, and contribute to existing rare disease registries

Coordinator

UNIVERSIDAD POLITECNICA DE MADRID
Net EU contribution
€ 685 000,00
Address
Calle Ramiro De Maeztu 7 Edificio Rectorado
28040 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (14)

DATAWIZARD SRL
Italy
Net EU contribution
€ 550 000,00
Address
Via Salaria 719
00138 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
SBA RESEARCH GEMEINNUTZIGE GMBH
Austria
Net EU contribution
€ 502 375,00
Other funding
€ 0,00
AUSTRALO INTERINNOV MARKETING LAB SL
Spain
Net EU contribution
€ 360 000,00
Address
Cl Pompeu Fabra 1 2 4
08860 Castelldefel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
Net EU contribution
€ 466 010,00
Address
Via Zamboni 33
40126 Bologna

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Region
Nord-Est Emilia-Romagna Bologna
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUNDACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES VICOMTECH
Spain
Net EU contribution
€ 550 975,00
Address
Paseo Mikeletegi Parque Tecnologico De Miramon 57
20009 Donostia San Sebastian

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Other funding
€ 0,00
THE EUROPEAN INSTITUTE FOR INNOVATION THROUGH HEALTH DATA
Belgium
Net EU contribution
€ 410 000,00
Address
Oude Mechelsestraat 165
1853 Strombeek-bever

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde
Activity type
Research Organisations
Other funding
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 435 937,50
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
HUMANITAS MIRASOLE SPA
Italy
Net EU contribution
€ 452 500,00
Address
Via Manzoni 56
20100 Rozzano (Mi)

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 335 350,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 311 250,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 354 287,50
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
GLSMED LEARNING HEALTH SA
Portugal
Net EU contribution
€ 303 125,00
Address
Rua Carlos Alberto De Mota Pinto Nr
1070 313 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Net EU contribution
€ 342 750,00
Address
Via 8 Febbraio 2
35122 Padova

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Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
NETCOMPANY-INTRASOFT SA
Luxembourg
Net EU contribution
€ 455 000,00
Address
Rue Nicolas Bove 2b
1253 Luxembourg

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Partners (1)

UNIVERSITY OF SOUTHAMPTON
United Kingdom
Net EU contribution
€ 0,00
Address
Highfield
SO17 1BJ Southampton

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Region
South East (England) Hampshire and Isle of Wight Southampton
Activity type
Higher or Secondary Education Establishments
Other funding
No data