Objective
280M of people worldwide suffers from major depressive disorders (MDD). Although a well-populated therapeutic landscape of anti-depre280M of people worldwide suffers from major depressive disorders (MDD). Although a well-populated therapeutic landscape of anti-depressants, the number of patients in remission is particularly low with not more than 6% of the patients who benefit from the current therapeutic journey.
OPADE objective is to identify key biomarkers that support the decision-making process of the healthcare providers.
The project focuses on the microbiota – brain -axis which plays a major role in mental health and in particular MDD. Through clinical investigations, the consortium partners will study the combination between genetics, epigenetics, microbiome and inflammatory networks to:
- Establish patient profiles to predict and optimise the efficacy of the antidepressants prescribed with an increase in the remission rate and reduction of impairment of real-life functioning,
- Establish the possible correlation between neuroinflammatory indices, target indicators of the microbiome, metabolomics, immune-profile linked, epigenomic, enzymatic algorithms,
- Evaluate molecular and non-molecular biomarkers that may represent predictive indices of recurrence
- Discover new molecular targets for a personalised approach,
- Improve the diagnostic accuracy for primary prevention,
- Evaluate retrospectively, using accurate anamnesis, the onset of depressive symptoms in adolescence.
- Establish how much and to what extent do blood biomarkers correlate with other specific biomarkers
350 patients between 14 and 50 years will be recruited in 6 EU and international countries for 24 months. Real-time EEG and patient cognitive assessment will be collected with blood, stool and saliva samples. Results and analysis will be used to train the AI / ML predictive tool, the main outcome of the project. A patient empowerment tool will be deployed over the project duration.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
84125 Salerno
Italy
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Participants (13)
80145 Napoli
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08290 Cerdanyola Del Valles (Barcelona)
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3300 Tienen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
400310 Cluj Napoca
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
14482 Potsdam
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
12618 Tallinn
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
67000 Strasbourg
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
01192 Arcaute Alava
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110221 Bogota
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53100 Siena
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9401 PJ Assen
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17190 Girona
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34083 Istanbul
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