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A Multiplexed Plasmo-Photonic Biosensing Platform For Rapid And Intelligent Sepsis Diagnosis At The Point-Of-Care

Objective

AMBROSIA aims to provide the foundations for a multi-sensing future-proof Point of Care Unit for sepsis diagnosis offered by a CMOS compatible toolkit and enhanced by on-chip photonic neural network technology to provide an accurate and rapid diagnosis. AMBROSIA will be investing in the established ultra-small-footprint and elevated sensitivity of integrated plasmo-photonic sensors reinforced by the well-known on-chip slow-light effect and micro-transfer printed lasers and photodiodes on Si3N4, as well as the functional processing and classification portfolio of integrated photonic neural network engines, towards painting the landscape of the next-coming disruption in sensor evolution, tailoring them in System-in-Package prototype assemblies, with the sensors being cheap disposable pluggable modules that can rapidly and accurately diagnose sepsis at the bedside in clinical environments. AMBROSIA targets to demonstrate a Point of Care Unit incorporating: i) a switchable sensor area array, with each sensor area facilitating a pluggable, 8-channel label-free plasmo-photonic sensor for sepsis diagnosis with a sensitivity over 130.000nm/RIU and a Limit of Detection below 10-8 RIU for each interferometric sensor, ii) an embedded Si3N4 photonic neural network processing and classifying at the same time the data from at least 7 biomarkers with zero-power providing in the first minutes an accurate and rapid diagnosis for sepsis, iii) Micro-transfer printed lasers and photodetectors on chip that will drastically decrease costs of both the sensing and neural network modules, and render the sensor arrays disposable.

Coordinator

ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Net EU contribution
€ 693 750,00
Address
Kedea Building, Tritis Septemvriou, Aristotle University Campus
546 36 Thessaloniki
Greece

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Region
Θεσσαλονίκη Κεντρική Μακεδονία Βόρεια Ελλάδα
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (10)

FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
Net EU contribution
€ 355 000,00
Address
Campus De La Uab Edifici Q Icn2
08193 Cerdanyola Del Valles

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITE DIJON BOURGOGNE
France
Net EU contribution
€ 252 980,00
Address
Esplanade Erasme Maison De L Universite
21078 Dijon Cedex

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Region
Bourgogne-Franche-Comté Bourgogne Côte-d’Or
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 124 357,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 48 553,00
X-CELEPRINT LIMITED
Ireland
Net EU contribution
€ 332 770,00
Address
6th Floor 2 Grand Canal Square
D02 A342 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 269 812,66
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
ARGOTECH AS
Czechia
Net EU contribution
€ 361 125,00
Address
Holubova 978
547 01 Nachod

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Severovýchod Královéhradecký kraj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
BIOPIX DNA TECHNOLOGY IKE
Greece
Net EU contribution
€ 370 000,00
Address
N. Plastira 100
700 13 Heraklion

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ηράκλειο Κρήτη Νησιά Αιγαίου
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
MICROLIQUID SL
Spain
Net EU contribution
€ 317 875,00
Address
Avenida Uribarri 19-1 Saiolan
20500 Arrasate Mondragon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noreste País Vasco Gipuzkoa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
PANEPISTIMIO IOANNINON
Greece
Net EU contribution
€ 209 800,00
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina

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Region
Ιωάννινα Ήπειρος Βόρεια Ελλάδα
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
SMART PHOTONICS BV
Netherlands
Net EU contribution
€ 402 040,00
Address
High Tech Campus 29
5656 AE Eindhoven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Partners (2)

LIGENTEC SA
Switzerland
Net EU contribution
€ 0,00
Address
Chemin De La Dent D Oche 1b Epfl Innovation Park Batiment L
1024 Ecublens

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Net EU contribution
€ 0,00
Address
Highfield
SO17 1BJ Southampton

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Region
South East (England) Hampshire and Isle of Wight Southampton
Activity type
Higher or Secondary Education Establishments
Other funding
No data