Objectif Tuberculosis and leprosy are still major health problems in many parts of the world improved case detection is one of the key factors for a better control of Mycobacterial diseases in the developing countries. In both tuberculosis and leprosy there is a need for improved detection of the causative organisms M.tuberculosis and M.leprae. simple, specific and sensitive detection and quantification of viable M.tuberculosis and M.leprae in tissue and body fluids, if correlated with clinical events, would provide an objective means of assessing relative bacterial load and efficacy of therapy. Existing methods do not meet the criteria of either simplicity and speed, sensitivity or specificity. The aim of the proposed research is to assess infection and excretion of viable mycobacteria in tuberculosis and leprosy patients. This will be achieved by the comparison of the results of conventional and novel molecular technology for : - the detection of tuberculosis and leprosy patients ; - the monitoring of mycobacterial viability in tuberculosis and leprosy patients during the course of treatment ; - the determination of M.tuberculosis infection among household contacts of newly diagnosed tuberculosis patients in a prospective study. This collaborative effort brings together unique patient populations, clinical expertise and laboratory expertise in the field of tuberculosis and leprosy to investigate, in a concerted manner, the clinical significance and pathobiological importance of newly developed advanced techniques in the course of human mycobacterial infection. The assessment of these tools Eor validity in an endemic country is unique to this study. it is envisaged that information from this project will ultimately be applied to better cont=01 of mycobacterial diseases. Champ scientifique medical and health sciencesclinical medicinepneumologytuberculosisnatural sciencesbiological sciencesmolecular biology Programme(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Koninklijk Instituut voor de Tropen Contribution de l’UE Aucune donnée Adresse 63,Mauritskade 1092 AD Amsterdam Pays-Bas Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Instituto Nacional de la Salud Portugal Contribution de l’UE Aucune donnée Adresse Largo Primeiro de Dezembre 4000 Porto Voir sur la carte Coût total Aucune donnée Raj-Pracha-Samasai Institute Thaïlande Contribution de l’UE Aucune donnée Adresse Bumrungmeung Road, Yodse 611 10200 Bangkok Voir sur la carte Coût total Aucune donnée
