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Immunisation against the pathogenic factors of T. Evansi. Its application to camels, swine and water buffaloes

Objetivo



With the advent of adequate diagnostic tools, chronic trypanosomiasis due to T.evansi is being more and more recognized as an economically important disease. The immunosuppression induced by the trypanosome decreases the resistance to other disease and is responsible for vaccine failure. Moreover, the disease is responsable for widespread abortions even in animals with mild chronic infection (camels, swine and waterbuffalo). Under TSDI and TS2, reagents were generated for serological diagnosis for antigen detection by PCR and for identification of T.evansi. These reagents contributed to an awareness of the extent of infection.
The study of the interaction between Trypanosomes and the host immune system has led to the discovery of Trypanosome factors responsible at least in part for.the pathological manifestations. These factors are : 1) a trypanosome immunosuppressive factor (TISF) responsible in vivo for the observed immunosuppression.
2) One or more trypanosome TNF inducing factors (TTIF).
These factors have now been partially purified.
The project aims at understanding how these factors interact with the host and with the trypanosome itself and whether immunisation against these factors will protect animals against the pathology induced by trypanosomes and in particular whether immunisation against the immunosuppressive factor will permit the infected animal to control the disease and eventually eliminate the infection.
T.evansi being a very homogeneous special and being the sole trypanosome in many regions is also an ideal model system not only for animal but also for human trypanosomiasis. Three of the partners involved have actively participated in the development of the diagnostic and epidimiological tools necessary for this research. The fourth partner (Dublin) will contribute to the biochemical aspects of the problem. The framework of this project will be used to train scientists in the Biochemistry (Dublin) Immunology (Brussels and Dublin) and genetics of Trypansomes (Brussels).

Tema(s)

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Convocatoria de propuestas

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Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

Vrije Universiteit Brussel
Aportación de la UE
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Dirección
65,Paardenstraat
1640 Rhode-Saint-Genèse
Bélgica

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Coste total
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Participantes (3)