Objetivo With the advent of adequate diagnostic tools, chronic trypanosomiasis due to T.evansi is being more and more recognized as an economically important disease. The immunosuppression induced by the trypanosome decreases the resistance to other disease and is responsible for vaccine failure. Moreover, the disease is responsable for widespread abortions even in animals with mild chronic infection (camels, swine and waterbuffalo). Under TSDI and TS2, reagents were generated for serological diagnosis for antigen detection by PCR and for identification of T.evansi. These reagents contributed to an awareness of the extent of infection. The study of the interaction between Trypanosomes and the host immune system has led to the discovery of Trypanosome factors responsible at least in part for.the pathological manifestations. These factors are : 1) a trypanosome immunosuppressive factor (TISF) responsible in vivo for the observed immunosuppression. 2) One or more trypanosome TNF inducing factors (TTIF). These factors have now been partially purified. The project aims at understanding how these factors interact with the host and with the trypanosome itself and whether immunisation against these factors will protect animals against the pathology induced by trypanosomes and in particular whether immunisation against the immunosuppressive factor will permit the infected animal to control the disease and eventually eliminate the infection. T.evansi being a very homogeneous special and being the sole trypanosome in many regions is also an ideal model system not only for animal but also for human trypanosomiasis. Three of the partners involved have actively participated in the development of the diagnostic and epidimiological tools necessary for this research. The fourth partner (Dublin) will contribute to the biochemical aspects of the problem. The framework of this project will be used to train scientists in the Biochemistry (Dublin) Immunology (Brussels and Dublin) and genetics of Trypansomes (Brussels). Ámbito científico natural sciencesbiological sciencesbiochemistrynatural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyimmunisationmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinepathology Programa(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Vrije Universiteit Brussel Aportación de la UE Sin datos Dirección 65,Paardenstraat 1640 Rhode-Saint-Genèse Bélgica Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Laboratoire Central Vétérinaire Mali Aportación de la UE Sin datos Dirección Route de Koulikoro 10 Bamako Ver en el mapa Coste total Sin datos Mahidol University Tailandia Aportación de la UE Sin datos Dirección Rama VI Road 10400 Bangkok Ver en el mapa Coste total Sin datos THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Irlanda Aportación de la UE Sin datos Dirección College Green 4 DUBLIN Ver en el mapa Coste total Sin datos