Objectif The main objective of this project is to standardise the available assay protocols, and to identify the various methodological problems, thus providing guidelines for the use of 32P-postlabelling in detecting carcinogen-DNA adducts so that this procedure can be rationally applied for monitoring human exposure to environmental carcinogens.Through a series of collaborative studies and brain-storming sessions the project will enable :1) to provide users of postlabelling methods in various fields with standardized protocols;2) to improve the methods of identification of individuals in cancer epidemiology who, due to their increased exposure to carcinogens or due to their inherited susceptibility, are at increased risk of developing cancer;3) to assess the effectiveness of measures to reduce exposure to carcinogens in the work place and4) to determine the extent to which the use of biomarkers such as DNA adducts are quantitative indicators of cancer risk in humans. Champ scientifique natural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesclinical medicineoncology Programme(s) FP3-ENV 1C - Specific research and technological development programme (EEC) in the field of the environment, 1990-1994 Thème(s) 040204 - Risks to health and the environment from chemical substances Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Centre International de Recherche sur le Cancer Contribution de l’UE Aucune donnée Adresse 150 cours Albert Thomas 69372 Lyon France Voir sur la carte Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUTE OF CANCER RESEARCH : ROYAL CANCER HOSPITAL Royaume-Uni Contribution de l’UE Aucune donnée Adresse Cotswold Road 15 SM2 5NG Sutton Voir sur la carte Coût total Aucune donnée
