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Vanadium derivates as transition state analogs in ribonucleases and as haptens for the production of antibodyenzymes (abysymes) with phosphatase activity

Objetivo



The two fundamental goals of this project are:
- The further study of vanadate compounds mainly nucleotides as stable transition-state analogs for pentavalent phosphate
intermediates in reactions catalyzed by ribonuclease-T1. This involves mainly 51V-NMR and X-ray crystallography.
- The exploitation of this property of vanadate compounds to mimic transition state intermediates of phosphohydrolysis reactions, to use them, now as haptens for the production of antibodies with phosphohydrolytic capacity.

Tema(s)

Data not available

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

Vrije Universiteit Brussel
Aportación de la UE
Sin datos
Dirección
65,Paardenstraat 65
1640 Rhode-Saint-Genèse
Bélgica

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Coste total
Sin datos

Participantes (2)