Objetivo Alcohol dehydrogenase polymorphism has never been studied in Poland. In the present project we will collect human samples (blood and biopsies) from the polish healthy and alcoholic population in order to analyze the isoenzyme composition, at both genotype and phenotype levels, and to correlate it with the alcoholic illness. Samples to be collected will be: blood from 40 alcoholics without cirrhosis of liver,40 alcoholics with cirrhosis, 40 healthy controls, 40 controls with viral cirrhosis and 20 alcoholics with pancreatitis. Liver biopsies will be also collected from individuals who require histological analysis. About 50 gastric biopsies will be also collected by endoscopy, in order to analyze gastric alcohol dehydrogenase. Blood samples will be send to the laboratories from the Bordeaux and Barcelona groups for genotype analyses. Phenotype and ADH activities will be measured in the polish laboratory. Polymorphism and activities of the polish individuals will be compared with that of the Western countries and in relation with the liver and gastric alcohol related illness. The addition of polish population to the Swedish, Spanish, French and German populations will give a wider picture of the ADH polymorfism in Europe. Programa(s) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Tema(s) 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Universitat Autonoma de Barcelona Aportación de la UE Sin datos Dirección 8193 Barcelona España Ver en el mapa Coste total Sin datos Participantes (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Jagellonian University Polonia Aportación de la UE Sin datos Dirección 10,Sniadeckick 31 531 Kraków Ver en el mapa Coste total Sin datos
