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Contenu archivé le 2022-12-23

Genetic and biochemical determinants of alcohol toxicity and addiction : the role of alcohol dehydrogenase isozymes

Objectif



Alcohol dehydrogenase polymorphism has never been studied in Poland. In the present project we will collect human samples (blood and biopsies) from the polish healthy and alcoholic
population in order to analyze the isoenzyme composition, at both genotype and phenotype levels, and to correlate it with the alcoholic illness.
Samples to be collected will be: blood from 40 alcoholics
without cirrhosis of liver,40 alcoholics with cirrhosis, 40
healthy controls, 40 controls with viral cirrhosis and 20
alcoholics with pancreatitis. Liver biopsies will be also
collected from individuals who require histological analysis. About 50 gastric biopsies will be also collected by endoscopy, in order to analyze gastric alcohol dehydrogenase.
Blood samples will be send to the laboratories from the
Bordeaux and Barcelona groups for genotype analyses. Phenotype and ADH activities will be measured in the polish laboratory. Polymorphism and activities of the polish individuals will be compared with that of the Western countries and in relation
with the liver and gastric alcohol related illness. The addition of polish population to the Swedish, Spanish, French and German populations will give a wider picture of the ADH polymorfism in Europe.

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

Universitat Autonoma de Barcelona
Contribution de l’UE
Aucune donnée
Adresse

8193 Barcelona
Espagne

Voir sur la carte

Coût total
Aucune donnée

Participants (1)