Objectif Alcohol dehydrogenase polymorphism has never been studied in Poland. In the present project we will collect human samples (blood and biopsies) from the polish healthy and alcoholic population in order to analyze the isoenzyme composition, at both genotype and phenotype levels, and to correlate it with the alcoholic illness. Samples to be collected will be: blood from 40 alcoholics without cirrhosis of liver,40 alcoholics with cirrhosis, 40 healthy controls, 40 controls with viral cirrhosis and 20 alcoholics with pancreatitis. Liver biopsies will be also collected from individuals who require histological analysis. About 50 gastric biopsies will be also collected by endoscopy, in order to analyze gastric alcohol dehydrogenase. Blood samples will be send to the laboratories from the Bordeaux and Barcelona groups for genotype analyses. Phenotype and ADH activities will be measured in the polish laboratory. Polymorphism and activities of the polish individuals will be compared with that of the Western countries and in relation with the liver and gastric alcohol related illness. The addition of polish population to the Swedish, Spanish, French and German populations will give a wider picture of the ADH polymorfism in Europe. Programme(s) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Thème(s) 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Universitat Autonoma de Barcelona Contribution de l’UE Aucune donnée Adresse 8193 Barcelona Espagne Voir sur la carte Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Jagellonian University Pologne Contribution de l’UE Aucune donnée Adresse 10,Sniadeckick 31 531 Kraków Voir sur la carte Coût total Aucune donnée