Objectif Project proposes preliminary studies or the training system for patients withspinal cord injury. One could expect that human spinal cord has potentialabilities for partial restoration of the neural circuitry responsible for locomTo use these abilities of a damaged spinal cordit i8 necessary: to normalize thof spinal structures (by using tendon vibration to enhance the tone or to supprspastics); to achieve partial or complete loading of legs; to reproduce leg joikinematics resembling those of normal step; to programmeafferent and efferent acin each step cycle (by FES and vibratory stimulation). Project includes a studyrole of some of these factors in control of locomotory movements. Three series experiments on healthy subjects will be performed. In the first series the possto evoke locomotory movements by programmed tendon vibration will be studied. Swill be positioned on his side.The thigh and shank of upper leg will be indepensuspended, so that leg movements will not produced any returning forces.4 similar vibrators will be attached to tendons of ankle and knee joint flexorsextensors. Sequence of their activation will be controlled by computer.EMG and joint angles will be recorded. By changing vibrators positions,parameteof vibration and activation pattern, the optimal conditions for evoking step-lileg movements will be found. In the second series the effect of loadine on the vibtatory eoked activity of leg muscles will be studied. Experiments will beperformed in sitting position. The amount oi feet loading will be changed by pasuspension of the thigh or by loading it with additional weight.Muscle activity will be evoked by tendon vibration as in series 1. The influencload will be estimated via EMG pattern of 4 leg muscles. Periodic load changes be also analized. The aim of the third series is to study interlimb coordinatioupright position. In these experiments supporting leg will be on a pedestal, soother leg will hang relaxed without any ground contact. EMG-activity of hangingwill be evoked by vibration. This activity is suppposed to change with changes position of supporting leg, corresponding to different phases of stance period step cycle. Programme(s) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Thème(s) 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur FONDAZIONE DON CARLO GNOCCHI - ONLUS Contribution de l’UE Aucune donnée Adresse Via Capecelatro 66 20148 MILANO Italie Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Institute for Information Transmission Problems - Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse 19,Ermolovoy 101447 Moskva Voir sur la carte Coût total Aucune donnée Ukrainian Academy of Sciences Ukraine Contribution de l’UE Aucune donnée Adresse 4,Bogomoletz Street 252601 Kiev Voir sur la carte Coût total Aucune donnée
