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A comprehensive study on the biology of multiple myeloma and its clinical applications in prognosis and therapy

Ziel



In the original project, the expertise of the Participating groups is combined in order to result in a multidisciplinary approach for the unravelling of the pathogenesis of multiple myeloma (MM).
The following topics in the pathophysiology of MM are studied : - adhesion molecules
- cytokine network
- cell cycle
- precursor cells
- genetic alterations
- immuno surveillance
As part of our topic on genetic alterations occuring in MM, the expression of a newly cloned gene encoding Metastasin 1 (mtsl) will be studied. Since the mtsl gene plays an important role in the control of tumor metastasis, its expression will be Studied at different stages of development of MM and compared with the level of its progression. In this way we hope to find whether mtsl protein is connected to tumor progression and if so, which features of MM cells are changed as a result of mts over-expression.

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Koordinator

Vrije Universiteit Brussel
EU-Beitrag
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Adresse
101,Laarbeeklaan
1090 Bruxelles
Belgien

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