Objective Objectives and content Manufacturers of food products, biopharmaceuticals and immobilized enzymes have a clear need for improved solid, particulate matrices which can be used for purification and immobilization of proteins (enzymes, antigens and antibodies). Today there are no materials which fulfil all the customers' demands on productivity, inertness, stability, flow properties and price. By removing this bottleneck it would be possible to develop large-scale industrial applications for solid matrices and to open up new market niches. Immobilized enzymes are potentially very useful as biocatalysts in food processing. Similarly, immobilized antigens and antibodies have potential for the very large scale purification of biopharmaceuticals. The objective of this project is to develop and evaluate new solid matrices which meet industry's needs. New polymerisation, surface modification and immobilization technology will be applied in the development of new matrix prototypes and a prototype process for large scale bead production. By improving the capacity, flow properties and kinetics of the matrices and by reducing the production cost it is expected that the performance/price ratio will increase by 5-10 times. Chemical leakage is expected below 10 ppb which is required for food applications. Enzymes will be purified by chromatography using the new matrices. The enzymes will be bound to activated matrices, and the immobilized enzymes with improved performance will be characterised. The immobilized enzymes will subsequently be used for development of new processes in the area of food processing. Immobilized antigens and antibodies will be applied to the development of new processes for purification of biopharmaceuticals. Processes which involve biocatalysts are favourable compared to traditional chemical processes since they save energy, are more specific and more environmental friendly. The consortium comprises a manufacturer of solid matrix beads (PhBio), a center of excellence in colloid, interface and polymer science (U Bristol) and a research institute specialized in surface chemistry (YKI). These partners design prototype matrices which are evaluated and used by the other partners: an enzyme manufacturer (NNAS), a food manufacturer (NESTEC) and a pharmaceutical company (ORION). Fields of science natural sciencesphysical sciencescondensed matter physicssoft matter physicsnatural scienceschemical sciencespolymer sciencessocial scienceseconomics and businesseconomicsproduction economicsproductivitynatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP4-BRITE/EURAM 3 - Specific research and technological development programme in the field of industrial and materials technologies, 1994-1998 Topic(s) 0202 - New methodologies for product design and manufacture Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Amersham Pharmacia Biotech AB EU contribution No data Address 30,Björkgatan 30 751 82 Uppsala Sweden See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all NESTEC S.A. Switzerland EU contribution No data Address Avenue Nestle 55 1800 VEVEY See on map Total cost No data Novo-Nordisk A/S Denmark EU contribution No data Address Novo Alle 2880 Bagsværd See on map Total cost No data Orion Corporation Ltd. Finland EU contribution No data Address 20101 Turku See on map Total cost No data UNIVERSITY OF BRISTOL United Kingdom EU contribution No data Address Cantock's Close BS8 1TS BRISTOL, CLIFTON See on map Total cost No data YKI - INSTITUTE FOR SURFACE CHEMISTRY Sweden EU contribution No data Address 45,Drottning Kristinas Väg 45 114 86 STOCKHOLM See on map Total cost No data