Obiettivo * To identify protective antigens in lymphatic Filariasis suitable for vaccine use.* To measure human antibody and T cell responses to these antigens. * To clone and express major T cell immunogens as recombinants.* To express selected recombinant filarial antigens for vaccine tests in animals.* To enhance expertise and research resources of endemic count scientists.Expected Outcome* Identification of a panel of immune individuals whose serological and lymphocyte reactivities will define key in immunity.* Identification of the major T cell antigens in lymphatic Filariasis, and their cloning and expression in a variety of vectors.* Evaluation of potential vaccine antigens against lymphatic Filariasis in rodent model systems.* Identification of subjects exposed to Filariasis transmission but show evident immunity.* Measurement of antibody responses to a range of recombinant antigens.* Identification and cloning of filarial antigens which most strongly stimulate T cells.* Analysis of different geographic strains of Brugia malayi.* Expression of filarial T cell for vaccine testing in rodent models. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Argomento(i) 03010302 - Research on the tools for prevention and the fight against the predominant diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore University of Edinburgh Contributo UE Nessun dato Indirizzo West Mains Road EH9 3JT Edinburgh Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo SW7 2AY London Mostra sulla mappa Costo totale Nessun dato LEIDEN UNIVERSITY Paesi Bassi Contributo UE Nessun dato Indirizzo 62,Wassenaarseweg 62 2300 RC LEIDEN Mostra sulla mappa Costo totale Nessun dato Shanghai Second Medical University Cina Contributo UE Nessun dato Indirizzo 280,South Chongqing Road 200025 Shanghai Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF INDONESIA Indonesia Contributo UE Nessun dato Indirizzo 6,Salemba Raya 6 10430 JAKARTA Mostra sulla mappa Costo totale Nessun dato
