Objective To search systematically for morphogenic genes (gene disruption by transposon insertion, differential mRNA display) To analyse the early events in morphogenesis involved in the regulation of the cell cycle and the transcription regulation To analyse the late events, e.g. the establishment of cell polarity by the actin cytoskeleton, vesicle transport and regulation of cell wall synthesis Candida albicans is the most common fungal pathogen of humans. It is capable of a dimorphic transition between two growth forms. The hyphal form appears well adapted to penetrate epithelia, and hence this growth form probably plays an important role in the progression from superficial to deep-seated infections. However, the molecular mechanisms by which hyphal growth is controlled in C. albicans remain obscure. This is partly due to the genetic intransigence of C. albicans which is diploid and asexual. However, the recent development of new tools for the molecualr dissection of this yeast is now allowing rapid progress which will bear fruit in the near future. Yarrowia lipolytica also provides a valuable model to study the regulation of fungal dimorphism. Like C. albicans it is dimorphic, but it is an apathogenic yeast which has been under genetic and molecular investigation for several years. Involvement of Y. lipolytica will definitely increase the scientific value of the project, because like C. albicans, its hyphae are different structurally to the pseudohyphae of S. cerevisiae. Conclusions made from results obtained on S. cerevisiae are not always directly applicable to C. albicans. In this context the subprojects will study one specific aspect of morphogenesis, i.e. the regulatory hierarchy that controls the switch from a yeast cell to a hypha. The individual groups will collaborate in three complementary lines of investigation, indicated on the top of this page. Fields of science agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingnatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencescell biologycell polaritynatural sciencesbiological sciencesmolecular biology Programme(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Topic(s) 4.2.2 - Pathogenesis of HIV and emerging of re-emerging diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Hans-Knoll-Institut für Naturstoff-Forschung e.V. EU contribution No data Address 11,Beutenbergstrasse 07745 Jena Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all Bayer AG Germany EU contribution No data Address Aprather Weg 42096 Wuppertal See on map Total cost No data HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Germany EU contribution No data Address Universitätsstraße 1, 26.12 40225 DUESSELDORF See on map Total cost No data INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE France EU contribution No data Address Route de Thiverval 78850 Thiverval-Grignon See on map Total cost No data UNIVERSITY OF ABERDEEN United Kingdom EU contribution No data Address Institute of Medical Sciences, Foresthill AB25 2ZD ABERDEEN See on map Total cost No data Universidad de Salamanca Spain EU contribution No data Address S/N,AVENIDA DEL CAMPO CHARRO 37071 SALAMANCA See on map Total cost No data Universitat de València Spain EU contribution No data Address S/N,AVDA. VICENT ANDRES ESTELLES, S/N. 46100 BURJASSOT-VALENCIA See on map Total cost No data
