Obiettivo To search systematically for morphogenic genes (gene disruption by transposon insertion, differential mRNA display) To analyse the early events in morphogenesis involved in the regulation of the cell cycle and the transcription regulation To analyse the late events, e.g. the establishment of cell polarity by the actin cytoskeleton, vesicle transport and regulation of cell wall synthesis Candida albicans is the most common fungal pathogen of humans. It is capable of a dimorphic transition between two growth forms. The hyphal form appears well adapted to penetrate epithelia, and hence this growth form probably plays an important role in the progression from superficial to deep-seated infections. However, the molecular mechanisms by which hyphal growth is controlled in C. albicans remain obscure. This is partly due to the genetic intransigence of C. albicans which is diploid and asexual. However, the recent development of new tools for the molecualr dissection of this yeast is now allowing rapid progress which will bear fruit in the near future. Yarrowia lipolytica also provides a valuable model to study the regulation of fungal dimorphism. Like C. albicans it is dimorphic, but it is an apathogenic yeast which has been under genetic and molecular investigation for several years. Involvement of Y. lipolytica will definitely increase the scientific value of the project, because like C. albicans, its hyphae are different structurally to the pseudohyphae of S. cerevisiae. Conclusions made from results obtained on S. cerevisiae are not always directly applicable to C. albicans. In this context the subprojects will study one specific aspect of morphogenesis, i.e. the regulatory hierarchy that controls the switch from a yeast cell to a hypha. The individual groups will collaborate in three complementary lines of investigation, indicated on the top of this page. Campo scientifico agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingnatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencescell biologycell polaritynatural sciencesbiological sciencesmolecular biology Programma(i) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Argomento(i) 4.2.2 - Pathogenesis of HIV and emerging of re-emerging diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore Hans-Knoll-Institut für Naturstoff-Forschung e.V. Contributo UE Nessun dato Indirizzo 11,Beutenbergstrasse 07745 Jena Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Bayer AG Germania Contributo UE Nessun dato Indirizzo Aprather Weg 42096 Wuppertal Mostra sulla mappa Costo totale Nessun dato HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Germania Contributo UE Nessun dato Indirizzo Universitätsstraße 1, 26.12 40225 DUESSELDORF Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Francia Contributo UE Nessun dato Indirizzo Route de Thiverval 78850 Thiverval-Grignon Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ABERDEEN Regno Unito Contributo UE Nessun dato Indirizzo Institute of Medical Sciences, Foresthill AB25 2ZD ABERDEEN Mostra sulla mappa Costo totale Nessun dato Universidad de Salamanca Spagna Contributo UE Nessun dato Indirizzo S/N,AVENIDA DEL CAMPO CHARRO 37071 SALAMANCA Mostra sulla mappa Costo totale Nessun dato Universitat de València Spagna Contributo UE Nessun dato Indirizzo S/N,AVDA. VICENT ANDRES ESTELLES, S/N. 46100 BURJASSOT-VALENCIA Mostra sulla mappa Costo totale Nessun dato