Obiettivo Chromosome 1, which is the largest human chromosome and harbours about 8% of the entire human genomic information, reveals in region lq21 a most remarkable clustering of genes that fulfil important functions in development and differentiation. Among twenty-five individual genes identified and physically mapped so far, fifteen encode structural proteins that are indispensable for terminal differentiation of the human epidermis and ten are genes for S100A small calcium binding proteins involved in signal transduction and cell cycle progression. Co-localisation of genes coding for calcium binding proteins with genes expressed late during epidermal differentiation is particularly intriguing since calcium levels tightly control the differentiation of epithelial cells and the expression of genes encoding epidermal structural proteins. Moreover, S100 proteins have been found to be differentially regulated in human cancer cells and region lq21 is often rearranged in human tumours. In addition, amplification of region lq21-q22 has recently been identified in human sarcomas. Since the groups joining for this proposal have previously been engaged in the identification and/or mapping of these important clustered genes, it appears appropriate to concentrate European resources for a combined, multidisciplinary effort aiming at a comprehensive characterisation of all known and novel genes residing in region lq21 and their tissue-, developmental-, and differentiation specific regulation. Likewise, the potential role of these genesin genetic disorders of keratinisation that obliterate the physical and chemical resistance of human epidermis will be analyzed as will be the effects of their disproportionate representation and abnormal regulation in tumorigenesis. Campo scientifico natural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticschromosomes Programma(i) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Argomento(i) 5.2 - Analysis of gene function and interaction Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore Humboldt-Universität zu Berlin Contributo UE Nessun dato Indirizzo 130,Spandauer Damm 14050 Berlin Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo Rue Jules Hetzel 9 92190 Meudon Mostra sulla mappa Costo totale Nessun dato Centre Hospitalier Universitaire Vaudois Svizzera Contributo UE Nessun dato Indirizzo 29,Rue du Bugnon 1011 Lausanne Mostra sulla mappa Costo totale Nessun dato Imperial Cancer Research Fund Regno Unito Contributo UE Nessun dato Indirizzo Lincoln's Inn Fields 44 WC2A 3PX LONDON Mostra sulla mappa Costo totale Nessun dato Institutt for Kreftforskning Norvegia Contributo UE Nessun dato Indirizzo Montebello 0310 Oslo Mostra sulla mappa Costo totale Nessun dato Rijksuniversiteit Leiden Paesi Bassi Contributo UE Nessun dato Indirizzo 55,Einsteinweg 2300 RA Leiden Mostra sulla mappa Costo totale Nessun dato The School of Pharmacy, University of London Regno Unito Contributo UE Nessun dato Indirizzo 29/39,Brunswick Square WC1N 1AX London Mostra sulla mappa Costo totale Nessun dato United Medical and Dental Schools of Guy's and St Thomas's Regno Unito Contributo UE Nessun dato Indirizzo St Thomas's Street London Bridge SE1 9RT London Mostra sulla mappa Costo totale Nessun dato Universität Zürich Svizzera Contributo UE Nessun dato Indirizzo 75,Steinwiesstrasse 8032 Zürich Mostra sulla mappa Costo totale Nessun dato
