Objetivo A substantial increase in the incidence of thyroid carcinoma in Belarus and Ukraine has been observed following the Chernobyl reactor accident. Several lines of evidence indicate that this phenomenon is causally related to theradiation released by the reactor. The outcome of differentiated thyroid carcinoma in children is largely dependent from the adequacy of the management,at the diagnostic, therapeutic and follow-up levels. In addition to the basic question of the causal relationship between the post-Chernobyl outbreak of thyroid cancer and exposure to the radioactive isotopes of iodine released by the reactor four main questions have been raised by lhe "epidemic" of post-Chernobyl thyroid carcinomas:1. Does thyroid cancer in young children differ in its clinical behaviour from that in older individuals?;2) Is there evidence suggesting that thyroid cancer caused by radiation behaves differently from sporadic thyroid cancer?;3) What should be the guidelines in managing children with thyroid cancer,especially in regard to surgical treatment and posl-operative medical treatment and follow-up procedures;4) Is there a possible role for the prophylactic use of iodine and or thyroxine to suppress pituitary TSH in the very large population exposed to the Chernobyl accident?It is expected that the present proposal will contribute to answer to these questions. The following specific objectives are the goal of the project:a) development and implementation of protocol for the correct use of l-thyroxin suppressive therapy in childhood thyroid cancer;b) new diagnostic imaging technique for the post-surgical monitoring of thyroid carcinoma, including the possible use of recombinant human TSH;c) study of autoimmune phenomena in radiation-induced childhood thyroid cancer;d) evaluation of the biological and clinical behaviour of radiation induced thyrcarcinoma as compared with non-radiation-induced thyroid carcinoma;e) the assessment of iodine deficiency and the need for iodine supplementation thyroid suppressive therapy in the prevention of radiation-induced thyroid canc Programa(s) EAEC-NFS 2 - Specific research and training programme in the field of nuclear safety and safeguards, 1994-1998 Tema(s) 050103 - Treatment of exposed individuals Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Università degli Studi di Pisa Aportación de la UE Sin datos Dirección Via Paradisa 56124 Cisanello - Pisa Italia Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Bayerische Julius-Maximilians-Universität Würzburg Alemania Aportación de la UE Sin datos Dirección Josef-Schneider-Straße 2 97080 Würzburg Ver en el mapa Coste total Sin datos Institut Gustave Roussy Francia Aportación de la UE Sin datos Dirección 39,Rue Camille Desmoulins 39 94805 Villejuif Ver en el mapa Coste total Sin datos Université Libre de Bruxelles Bélgica Aportación de la UE Sin datos Dirección 322,Rue Haut 1000 Bruxelles Ver en el mapa Coste total Sin datos
