Objetivo For a better understanding and improved clinical use of the antitumour drugs cisplatin and carboplatin detailed studies of the DNA binding are highly important. Given the narrow range of tumours that can be treated by these compounds, and given their severe toxic side effects, a desperate need exists for the development of totally new Pt compounds. The major objective of this joint research is to design and synthesize novel Pt compounds with improved antitumour properties. The new compounds will be structurally characterized, and checked for antitumour properties and for binding to nucleic acids. Special attention will be given to a study of the mechanism of the antitumour properties of the newly synthesized platinum compounds. The research will consist of: the design and synthesis of new Pt compounds; the study of their biological properties; the binding of the compounds to small synthetic fragments of nucleic acids and their precise structures; and the binding to DNA and RNA from several sources and the structural changes occurring as a result of metal binding. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) 36 - Biochemistry and New Pharmaceutical Compounds Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador Rijksuniversiteit Leiden Aportación de la UE Sin datos Dirección Einsteinweg 55 2333 CC Leiden Países Bajos Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Russian Academy of Sciences Rusia Aportación de la UE Sin datos Dirección 117907 Moscow Ver en el mapa Coste total Sin datos St. Petersburg State University Rusia Aportación de la UE Sin datos Dirección 198904 St. Petersburg Ver en el mapa Coste total Sin datos Université René Descartes - Paris V Francia Aportación de la UE Sin datos Dirección 75270 Paris Ver en el mapa Coste total Sin datos
