Objectif Compounds containing three-membered carbon rings occur widely in nature and show a variety of biochemical effects which control key functions in both animals and plants. Synthetic analogues continue to be of wide interest to the chemical and pharmaceutical industries. The reason for the particular importance of these compounds may lie in their unusual structures and inherent strain energy, and in their ability to release that strain on interaction with a biological receptor.The groups in France, Germany and UK are extensively involved in the development of new methods for the synthesis of cyclopropanes, methylenecyclopropanes and cyclopropenes, and in the applications of these to routes to e.g. hypoglycaemic 2,3- and 3,4-methanoamino acids, fatty acid desaturase inhibitors (which are of potential application in the treatment of cancer, AIDS, heart disease and tuberculosis) and novel environmentally friendly methods of insect control. The NIS groups are leading experts in the fundamental chemistry of cyclopropenes and cyclopropanes and in the theoretical and experimental analysis of the factors controlling their reactivity. The aim of this research will be to provide NIS groups with the possibility of applying their fundamental expertise to a wide range of synthetic methods and biologically significant compounds, and in particular to develop a model for predicting the rate and stereoselectivity of addition and cycloaddition reactions of cyclopropenes with a key target of producing optically pure cyclopropanes. The programme will be effected primarily by supporting postdoctors and postgraduate students who will spend extended periods in a laboratory in western Europe, coupled with staff visits in both directions. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 36 - Biochemistry and New Pharmaceutical Compounds Appel à propositions Data not available Régime de financement Data not available Coordinateur University of Wales, Bangor Contribution de l’UE Aucune donnée Adresse LL57 2DG Bangor Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Georg-August Universität of Göttingen Allemagne Contribution de l’UE Aucune donnée Adresse 37077 Göttingen Voir sur la carte Coût total Aucune donnée Kazan Medical State University Russie Contribution de l’UE Aucune donnée Adresse 420012 Kazan Voir sur la carte Coût total Aucune donnée Kazan State Technological University Russie Contribution de l’UE Aucune donnée Adresse 420015 Kazan Voir sur la carte Coût total Aucune donnée Moscow State University ' M.V. Lomonosov ' Russie Contribution de l’UE Aucune donnée Adresse 119899 Moscow Voir sur la carte Coût total Aucune donnée State University of Belarus Biélorussie Contribution de l’UE Aucune donnée Adresse 220050 Minsk Voir sur la carte Coût total Aucune donnée Université de Paris-Sud - Paris XI France Contribution de l’UE Aucune donnée Adresse 91405 Orsay Voir sur la carte Coût total Aucune donnée
