Obiettivo Release of neurotransmitters from neuronal cells is a basis for neuron-neuron communication and, in general, for the working of the brain. The research will use the neurosecretogogue a-latrotoxin (a-LTX) and in vitro culture of chromaffin cells of neuronal origin to study neurosecretion. a-LTX induces secretion of catecholamine in calcium-dependent manner from both intact and permeabilised cells. The toxin interacts directly with the neurosecretory machinery. The research unites expertise in toxin handling and protein biochemistry at the Shemyakin Institute with expertise in state-of-the-art calcium measurement and imaging techniques at University College London (UCL). The participation of scientists from both research groups will give them access to resources not yet available at the Shemyakin Institute and will facilitate the setting up of such resources at a future date.The aim of the research is to identify the molecular basis of the interaction between calcium and a-latrotoxin using a combination of cell physiology, cell biology and biochemistry. This will lead to a fundamental insight into the process of neurotransmitter release, and thus to an understanding of brain mechanisms. Programma(i) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Argomento(i) 42 - Physical Chemical Biology Invito a presentare proposte Data not available Meccanismo di finanziamento Data not available Coordinatore UNIVERSITY COLLEGE LONDON Contributo UE Nessun dato Indirizzo Gower Street LONDON Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Russian Academy of Sciences Russia Contributo UE Nessun dato Indirizzo 117871 Moscow Mostra sulla mappa Costo totale Nessun dato