Structural and functional properties of molten globule state of proteins

Projektinformationen

ID Finanzhilfevereinbarung: INTAS-93-3472

Startdatum 1 Mai 1995

Enddatum 30 April 1996

Finanziert unter

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Gesamtkosten € 0,00

EU-Beitrag € 50 000,00

Koordiniert durch

Università degli Studi di Parma
Italy

Ziel

The physical state of protein molecules known as the molten globule state has been discovered and extensively characterised at the Institute of Protein Research, Pushchino, Russia. It has been proposed, or proved on an experimental basis, that this state plays a physiological role in several processes.

This collaborative project will consist in the study of: the influence of conditions that mimic the environment near membranes on the physical state of retinol-binding proteins; the role of structural transitions in the process of targeted delivery of vitamin A derivatives to physiological acceptors; and the structural features of the molten globule state of all proteins of distinct topologies, ranging from all helical to all sheet proteins, including retinol-binding protein, cellular retinol-binding protein, lysozyme, a-lactamase, as well as recombinant chimeric proteins.

The methodologies that will be used include high resolution NMR, UV circular dichroism, fluorescence, IR spectroscopy, microcalorimetry, hydrodynamic techniques and X-ray crystallography.

Programm/Programme

• IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Thema/Themen

• 42 - Physical Chemical Biology

Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

Data not available

Koordinator

Università degli Studi di Parma

• EU-Beitrag: Keine Daten
• Adresse: Viale delle Scienze 78 ; 43100 Parma ; Italien
• Gesamtkosten: Keine Daten

Beteiligte (3)

Interdisciplinair Research Centrum

Belgien

• EU-Beitrag: Keine Daten
• Adresse: 8500 Kortrijk
• Gesamtkosten: Keine Daten

Russian Academy of Sciences

Russland

• EU-Beitrag: Keine Daten
• Adresse: 142292 Pushchino, Moscow Region
• Gesamtkosten: Keine Daten

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Vereinigtes Königreich

• EU-Beitrag: Keine Daten
• Adresse: South Parks Road ; OX1 3QT OXFORD
• Gesamtkosten: Keine Daten