Skip to main content
European Commission logo print header
Content archived on 2022-12-23

Energy transduction in muscle: a molecular description of the dynamics of muscular contraction

Objective



Muscle contraction, and its regulation, is a universal biological function in animals. It occurs through the interactions of several proteins, some of which are organised in filamentous arrays. The immediate source of chemical energy that is required for the muscle to do work comes from the hydrolysis of ATP. The molecular mechanism by which the chemical energy of ATP hydrolysis is converted into mechanical work is of fundamental biological interest. Muscular contraction and its regulation are also matters of clinical significance because defects in skeletal, cardiac and smooth muscle are a major cause of human disability. The underlying physiology of muscle in its various pathological states is an important area of basic research.

In the project time-resolved mechanical and preliminary T-Jump experiments with a synchrotron radiation facility will be done. Furthermore a magnet controlled in vitro mobility assay will be constructed and set up. With the facility velocity, force and power out put measurements will be performed. A cross-bridge kinetic model of sarcomere dynamics will be developed and investigated.

This project will give young scientists from Russia the opportunity for a training in protein biochemistry.

Call for proposal

Data not available

Funding Scheme

Data not available

Coordinator

MRC National Institute for Medical Research
EU contribution
No data
Address
The Ridgeway Mill Hill
NW7 1AA London
United Kingdom

See on map

Total cost
No data

Participants (5)