Objective Muscle contraction, and its regulation, is a universal biological function in animals. It occurs through the interactions of several proteins, some of which are organised in filamentous arrays. The immediate source of chemical energy that is required for the muscle to do work comes from the hydrolysis of ATP. The molecular mechanism by which the chemical energy of ATP hydrolysis is converted into mechanical work is of fundamental biological interest. Muscular contraction and its regulation are also matters of clinical significance because defects in skeletal, cardiac and smooth muscle are a major cause of human disability. The underlying physiology of muscle in its various pathological states is an important area of basic research. In the project time-resolved mechanical and preliminary T-Jump experiments with a synchrotron radiation facility will be done. Furthermore a magnet controlled in vitro mobility assay will be constructed and set up. With the facility velocity, force and power out put measurements will be performed. A cross-bridge kinetic model of sarcomere dynamics will be developed and investigated. This project will give young scientists from Russia the opportunity for a training in protein biochemistry. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Topic(s) 43 - Physiology and Fundamental Medical Science Call for proposal Data not available Funding Scheme Data not available Coordinator MRC National Institute for Medical Research EU contribution No data Address The Ridgeway Mill Hill NW7 1AA London United Kingdom See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all Academic Medical Centre Netherlands EU contribution No data Address 1105 AZ Amsterdam See on map Total cost No data Institute of Physiology Russia EU contribution No data Address 620014 Yekaterinburg See on map Total cost No data King's College London United Kingdom EU contribution No data Address 26-29 Drury Lane WC2B 5RL London See on map Total cost No data Moscow State University M.V. Lomonosov Russia EU contribution No data Address 117192 Moscow See on map Total cost No data UNIVERSITY OF FLORENCE Italy EU contribution No data Address Viale Morgagni 63 50134 Firenze See on map Total cost No data