Cel New lines of research are being proposed on the mode of action of established and potential antiepileptic drugs. These are based on recent developments in the study of excitatory and inhibitory amino acid neurotransmitters, progress in nitric oxide research and advances in the neurobiology of oxidative stress and its role in tissue injury. Excitatory and inhibitory amino acids play a crucial role in the initiation, spread and termination of epileptic activity. They are also important in the neuronal pathology that follows prolonged seizures. Nitric oxide (NO) has recently been shown to be a novel class of neurotransmitter and cell to cell signalling agent. It is produced in neurons and glia by the enzyme nitric oxide synthase (NOS), and induces the formation of cGMP by activation of guanylate cyclase. It has also been shown to contribute to glutamate excitotoxicity. Its role in epileptic activity is at present controversial, both proconvulsant and anticonvulsant effects have been described. Lipid peroxidation may participate in epileptic activity. This phenomena will be investigated using NO donors, NOS inhibitors and free radical scavengers in various experimental models of epilepsy. Their influence will be compared with that of established anticonvulsant drugs on various electrophysiological parameters including convulsive threshold afterdischarge duration. In the same way, their effects on various neurochemical parameters such as amino acid content and amino acid release and uptake, and alpha-tocopherol and dien-conjugate concentration in various brain areas will be compared with those of known modifiers of glutamate release and of lipid peroxidation state. The effect of these agents on the neurochemical and pathological consequences of prolonged seizures will also be studied. Program(-y) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Temat(-y) 45 - Pharmacology Zaproszenie do składania wniosków Data not available System finansowania Data not available Koordynator Institute of Psychiatry Wkład UE Brak danych Adres De Crespigny Park Camberwell SE5 8AF London Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Russian Academy of Sciences Rosja Wkład UE Brak danych Adres 125315 Moscow Zobacz na mapie Koszt całkowity Brak danych University of Tampere Finlandia Wkład UE Brak danych Adres 33101 Tampere Zobacz na mapie Koszt całkowity Brak danych
